Cytomegalovirus antigenemia in the differential diagnosis of pulmonary infiltrates after allogeneic bone marrow transplantation

H. Gondo, M. Harada, T. Minematsu, Koichi Akashi, S. Hayashi, S. Taniguchi, K. Yamasaki, T. Shibuya, Y. Takamatsu, T. Eto

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

抄録

For the differential diagnosis of pulmonary infiltrates after bone marrow transplantation, cytomegalovirus (CMV) antigenemia was evaluated in 9 episodes of pneumonia which developed in 7 allogeneic marrow transplant patients between 9 and 495 days after transplant. The diagnosis of lung infiltration was made based on clinical findings including histological, cytological or microbiological examinations using bronchoalveolar lavage fluid specimens, sputum or lung tissue. The CMV antigen-positive leukocytes were detected with a direct immunoperoxidase technique using a peroxidase-labeled monoclonal antibody (HRP-C7) against CMV immediate early antigen. The episodes included 2 CMV pneumonias, 1 pneumocystis carinii pneumonia, 1 adenovirus pneumonia, 1 bacterial pneumonia, 1 bacterial and fungal pneumonia, 2 idiopathic pneumonias and 1 capillary leak syndrome associated with hyper acute GVHD. The CMV antigenemia became positive only in two patients with CMV pneumonia and the number of CMV antigen-positive leukocytes exceeded 10 per 50000 WBCs. The CMV antigenemia test required only 24 hours to obtain results. These observations suggest that the detection of CMV antigenemia is of great value in the differential diagnosis of pulmonary infiltrates in marrow transplant patients.

元の言語英語
ページ(範囲)1438-1444
ページ数7
ジャーナル[Rinshō ketsueki] The Japanese journal of clinical hematology
34
発行部数11
出版物ステータス出版済み - 1 1 1993
外部発表Yes

Fingerprint

Homologous Transplantation
Cytomegalovirus
Bone Marrow Transplantation
Differential Diagnosis
Lung
Pneumonia
Bacterial Pneumonia
HLA Antigens
Transplants
Capillary Leak Syndrome
Bone Marrow
Pneumocystis Pneumonia
Bronchoalveolar Lavage Fluid
Sputum
Immunoenzyme Techniques
Adenoviridae
Peroxidase
Monoclonal Antibodies

All Science Journal Classification (ASJC) codes

  • Medicine(all)

これを引用

Cytomegalovirus antigenemia in the differential diagnosis of pulmonary infiltrates after allogeneic bone marrow transplantation. / Gondo, H.; Harada, M.; Minematsu, T.; Akashi, Koichi; Hayashi, S.; Taniguchi, S.; Yamasaki, K.; Shibuya, T.; Takamatsu, Y.; Eto, T.

:: [Rinshō ketsueki] The Japanese journal of clinical hematology, 巻 34, 番号 11, 01.01.1993, p. 1438-1444.

研究成果: ジャーナルへの寄稿記事

Gondo, H, Harada, M, Minematsu, T, Akashi, K, Hayashi, S, Taniguchi, S, Yamasaki, K, Shibuya, T, Takamatsu, Y & Eto, T 1993, 'Cytomegalovirus antigenemia in the differential diagnosis of pulmonary infiltrates after allogeneic bone marrow transplantation', [Rinshō ketsueki] The Japanese journal of clinical hematology, 巻. 34, 番号 11, pp. 1438-1444.
Gondo, H. ; Harada, M. ; Minematsu, T. ; Akashi, Koichi ; Hayashi, S. ; Taniguchi, S. ; Yamasaki, K. ; Shibuya, T. ; Takamatsu, Y. ; Eto, T. / Cytomegalovirus antigenemia in the differential diagnosis of pulmonary infiltrates after allogeneic bone marrow transplantation. :: [Rinshō ketsueki] The Japanese journal of clinical hematology. 1993 ; 巻 34, 番号 11. pp. 1438-1444.
@article{2a1573eb32a54017840e32e834f75719,
title = "Cytomegalovirus antigenemia in the differential diagnosis of pulmonary infiltrates after allogeneic bone marrow transplantation",
abstract = "For the differential diagnosis of pulmonary infiltrates after bone marrow transplantation, cytomegalovirus (CMV) antigenemia was evaluated in 9 episodes of pneumonia which developed in 7 allogeneic marrow transplant patients between 9 and 495 days after transplant. The diagnosis of lung infiltration was made based on clinical findings including histological, cytological or microbiological examinations using bronchoalveolar lavage fluid specimens, sputum or lung tissue. The CMV antigen-positive leukocytes were detected with a direct immunoperoxidase technique using a peroxidase-labeled monoclonal antibody (HRP-C7) against CMV immediate early antigen. The episodes included 2 CMV pneumonias, 1 pneumocystis carinii pneumonia, 1 adenovirus pneumonia, 1 bacterial pneumonia, 1 bacterial and fungal pneumonia, 2 idiopathic pneumonias and 1 capillary leak syndrome associated with hyper acute GVHD. The CMV antigenemia became positive only in two patients with CMV pneumonia and the number of CMV antigen-positive leukocytes exceeded 10 per 50000 WBCs. The CMV antigenemia test required only 24 hours to obtain results. These observations suggest that the detection of CMV antigenemia is of great value in the differential diagnosis of pulmonary infiltrates in marrow transplant patients.",
author = "H. Gondo and M. Harada and T. Minematsu and Koichi Akashi and S. Hayashi and S. Taniguchi and K. Yamasaki and T. Shibuya and Y. Takamatsu and T. Eto",
year = "1993",
month = "1",
day = "1",
language = "English",
volume = "34",
pages = "1438--1444",
journal = "[Rinsho ketsueki] The Japanese journal of clinical hematology",
issn = "0485-1439",
publisher = "Nihon Rinsho Ketsueki Gakkai/Japan Society of Clinical Hematology",
number = "11",

}

TY - JOUR

T1 - Cytomegalovirus antigenemia in the differential diagnosis of pulmonary infiltrates after allogeneic bone marrow transplantation

AU - Gondo, H.

AU - Harada, M.

AU - Minematsu, T.

AU - Akashi, Koichi

AU - Hayashi, S.

AU - Taniguchi, S.

AU - Yamasaki, K.

AU - Shibuya, T.

AU - Takamatsu, Y.

AU - Eto, T.

PY - 1993/1/1

Y1 - 1993/1/1

N2 - For the differential diagnosis of pulmonary infiltrates after bone marrow transplantation, cytomegalovirus (CMV) antigenemia was evaluated in 9 episodes of pneumonia which developed in 7 allogeneic marrow transplant patients between 9 and 495 days after transplant. The diagnosis of lung infiltration was made based on clinical findings including histological, cytological or microbiological examinations using bronchoalveolar lavage fluid specimens, sputum or lung tissue. The CMV antigen-positive leukocytes were detected with a direct immunoperoxidase technique using a peroxidase-labeled monoclonal antibody (HRP-C7) against CMV immediate early antigen. The episodes included 2 CMV pneumonias, 1 pneumocystis carinii pneumonia, 1 adenovirus pneumonia, 1 bacterial pneumonia, 1 bacterial and fungal pneumonia, 2 idiopathic pneumonias and 1 capillary leak syndrome associated with hyper acute GVHD. The CMV antigenemia became positive only in two patients with CMV pneumonia and the number of CMV antigen-positive leukocytes exceeded 10 per 50000 WBCs. The CMV antigenemia test required only 24 hours to obtain results. These observations suggest that the detection of CMV antigenemia is of great value in the differential diagnosis of pulmonary infiltrates in marrow transplant patients.

AB - For the differential diagnosis of pulmonary infiltrates after bone marrow transplantation, cytomegalovirus (CMV) antigenemia was evaluated in 9 episodes of pneumonia which developed in 7 allogeneic marrow transplant patients between 9 and 495 days after transplant. The diagnosis of lung infiltration was made based on clinical findings including histological, cytological or microbiological examinations using bronchoalveolar lavage fluid specimens, sputum or lung tissue. The CMV antigen-positive leukocytes were detected with a direct immunoperoxidase technique using a peroxidase-labeled monoclonal antibody (HRP-C7) against CMV immediate early antigen. The episodes included 2 CMV pneumonias, 1 pneumocystis carinii pneumonia, 1 adenovirus pneumonia, 1 bacterial pneumonia, 1 bacterial and fungal pneumonia, 2 idiopathic pneumonias and 1 capillary leak syndrome associated with hyper acute GVHD. The CMV antigenemia became positive only in two patients with CMV pneumonia and the number of CMV antigen-positive leukocytes exceeded 10 per 50000 WBCs. The CMV antigenemia test required only 24 hours to obtain results. These observations suggest that the detection of CMV antigenemia is of great value in the differential diagnosis of pulmonary infiltrates in marrow transplant patients.

UR - http://www.scopus.com/inward/record.url?scp=0027691004&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027691004&partnerID=8YFLogxK

M3 - Article

C2 - 8254905

AN - SCOPUS:0027691004

VL - 34

SP - 1438

EP - 1444

JO - [Rinsho ketsueki] The Japanese journal of clinical hematology

JF - [Rinsho ketsueki] The Japanese journal of clinical hematology

SN - 0485-1439

IS - 11

ER -