Cytoskeletal role in the contractile dysfunction of hypertrophied myocardium

Hiroyuki Tsutsui, Kazuaki Ishihara, George Cooper IV

研究成果: Contribution to journalArticle査読

233 被引用数 (Scopus)

抄録

Cardiac hypertrophy in response to systolic pressure loading frequently results in contractile dysfunction of unknown cause. In the present study, pressure loading increased the microtubule component of the cardiac muscle cell cytoskeleton, which was responsible for the cellular contractile dysfunction observed. The linked microtubule and contractile abnormalities were persistent and thus may have significance for the deterioration of initially compensatory cardiac hypertrophy into congestive heart failure.

本文言語英語
ページ(範囲)682-687
ページ数6
ジャーナルScience
260
5108
DOI
出版ステータス出版済み - 1993

All Science Journal Classification (ASJC) codes

  • 一般

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