Cytotoxic acacic acid glycosides from the roots of Albizia coriaria

Olivier Placide Noté, Anne Claire Mitaine-Offer, Tomofumi Miyamoto, Thomas Paululat, Jean François Mirjolet, Olivier Duchamp, Dieudonné Emmanuel Pegnyemb, Marie Aleth Lacaille-Dubois

研究成果: Contribution to journalArticle査読

33 被引用数 (Scopus)

抄録

Two new oleanane-type saponins, coriariosides A (1) and B (2), along with a known saponin, gummiferaoside C (3), were isolated from the roots of Albizia coriaria. Their structures were established by extensive analysis of 1D and 2D NMR experiments (COSY, ROESY, TOCSY, HSQC, and HMBC) and mass spectrometry. Compounds 1 and 3 when tested for cytotoxicity against two colorectal human cancer cells showed activity against the HCT 116 (IC50 4.2 μM for 1 and 2.7 μM for 3) and HT-29 (IC50 6.7 μM for 1 and 7.9 μM for 3) cell lines.

本文言語英語
ページ(範囲)1725-1730
ページ数6
ジャーナルJournal of Natural Products
72
10
DOI
出版ステータス出版済み - 10 23 2009

All Science Journal Classification (ASJC) codes

  • 分析化学
  • 分子医療
  • 薬理学
  • 薬科学
  • 創薬
  • 補完代替医療
  • 有機化学

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