Cytotoxic and antioxidant compounds from the stem bark of Goniothalamus tapisoides mat salleh

Rosalind Pei Theng Kim, Vicky Bihud, Khalit Bin Mohamad, Kok Hoong Leong, Jamaludin Bin Mohamad, Fasihuddin Bin Ahmad, Hazrina Hazni, Noraini Kasim, Siti Nadiah Abdul Halim, Khalijah Awang

    研究成果: Contribution to journalArticle査読

    14 被引用数 (Scopus)

    抄録

    Eleven compounds: goniomicin A (1), goniomicin B (2), goniomicin C (3), goniomicin D (4), tapisoidin (5), goniothalamin (6), 9-deoxygoniopypyrone (7), pterodondiol (8), liriodenine (9), benzamide (10) and cinnamic acid (11), were isolated from the stem bark of Goniothalamus tapisoides. All compounds were identified by spectroscopic analysis and, for known compounds, by comparison with published data. Goniothalamin (6) exhibited mild cytotoxic activity towards a colon cancer cell line (HT-29), with an IC50 value of 64.17 ± 5.60 μM. Goniomicin B (2) give the highest antioxidant activity in the DPPH assay among all compounds tested, with an IC50 of 0.207 μM.

    本文言語英語
    ページ(範囲)128-139
    ページ数12
    ジャーナルMolecules
    18
    1
    DOI
    出版ステータス出版済み - 1 2013

    All Science Journal Classification (ASJC) codes

    • 分析化学
    • 化学(その他)
    • 分子医療
    • 薬科学
    • 創薬
    • 物理化学および理論化学
    • 有機化学

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