D-RECS (1) a gene regulation system responding to protein kinase signal

Jun Oishi, Kenji Kawamura, Moeko Ijuin, Jeong Hun Kang, Daisuke Asai, Yuko Sato, Yoshiki Katayama

研究成果: Contribution to conferencePaper査読


We recently proposed the novel gene-regulation system responding to cAMP-dependent protein kinase (PKA). For this system, we used the cationic polymer which includes the oligopeptide that is the substrate of PKA. Since this polymer forms complexes with DNA, the gene expression was totally suppressed. However, when PKA is being continuously activated, anions were inserted in the polymer by phospholilating the peptides of side chains, the complex of DNA and polymer collapses and transcription of the gene is activated. We attempted to apply this system to living cell, and were successful to intracellular target signal-responsive regulation of delivered gene-expression.

出版ステータス出版済み - 10 19 2006
イベント55th SPSJ Annual Meeting - Nagoya, 日本
継続期間: 5 24 20065 26 2006


その他55th SPSJ Annual Meeting

All Science Journal Classification (ASJC) codes

  • Engineering(all)

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