D-RECS (1) a gene regulation system responding to protein kinase signal

Jun Oishi, Kenji Kawamura, Moeko Ijuin, Jeong Hun Kang, Daisuke Asai, Yuko Sato, Yoshiki Katayama

研究成果: 会議への寄与タイプ論文

抄録

We recently proposed the novel gene-regulation system responding to cAMP-dependent protein kinase (PKA). For this system, we used the cationic polymer which includes the oligopeptide that is the substrate of PKA. Since this polymer forms complexes with DNA, the gene expression was totally suppressed. However, when PKA is being continuously activated, anions were inserted in the polymer by phospholilating the peptides of side chains, the complex of DNA and polymer collapses and transcription of the gene is activated. We attempted to apply this system to living cell, and were successful to intracellular target signal-responsive regulation of delivered gene-expression.

元の言語英語
ページ数1
出版物ステータス出版済み - 10 19 2006
イベント55th SPSJ Annual Meeting - Nagoya, 日本
継続期間: 5 24 20065 26 2006

その他

その他55th SPSJ Annual Meeting
日本
Nagoya
期間5/24/065/26/06

Fingerprint

Gene expression
Proteins
Polymers
DNA
Transcription
Peptides
Negative ions
Genes
Cells
Substrates

All Science Journal Classification (ASJC) codes

  • Engineering(all)

これを引用

Oishi, J., Kawamura, K., Ijuin, M., Kang, J. H., Asai, D., Sato, Y., & Katayama, Y. (2006). D-RECS (1) a gene regulation system responding to protein kinase signal. 論文発表場所 55th SPSJ Annual Meeting, Nagoya, 日本.

D-RECS (1) a gene regulation system responding to protein kinase signal. / Oishi, Jun; Kawamura, Kenji; Ijuin, Moeko; Kang, Jeong Hun; Asai, Daisuke; Sato, Yuko; Katayama, Yoshiki.

2006. 論文発表場所 55th SPSJ Annual Meeting, Nagoya, 日本.

研究成果: 会議への寄与タイプ論文

Oishi, J, Kawamura, K, Ijuin, M, Kang, JH, Asai, D, Sato, Y & Katayama, Y 2006, 'D-RECS (1) a gene regulation system responding to protein kinase signal', 論文発表場所 55th SPSJ Annual Meeting, Nagoya, 日本, 5/24/06 - 5/26/06.
Oishi J, Kawamura K, Ijuin M, Kang JH, Asai D, Sato Y その他. D-RECS (1) a gene regulation system responding to protein kinase signal. 2006. 論文発表場所 55th SPSJ Annual Meeting, Nagoya, 日本.
Oishi, Jun ; Kawamura, Kenji ; Ijuin, Moeko ; Kang, Jeong Hun ; Asai, Daisuke ; Sato, Yuko ; Katayama, Yoshiki. / D-RECS (1) a gene regulation system responding to protein kinase signal. 論文発表場所 55th SPSJ Annual Meeting, Nagoya, 日本.1 p.
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AU - Sato, Yuko

AU - Katayama, Yoshiki

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