D-RECS (1) a gene regulation system responding to protein kinase signal

Jun Oishi; Kenji Kawamura; Moeko Ijuin; Jeong Hun Kang; Daisuke Asai; Yuko Sato; Yoshiki Katayama

D-RECS (1) a gene regulation system responding to protein kinase signal

Jun Oishi, Kenji Kawamura, Moeko Ijuin, Jeong Hun Kang, Daisuke Asai, Yuko Sato, Yoshiki Katayama

機能組織化学

研究成果: Contribution to conference › Paper › 査読

抄録

We recently proposed the novel gene-regulation system responding to cAMP-dependent protein kinase (PKA). For this system, we used the cationic polymer which includes the oligopeptide that is the substrate of PKA. Since this polymer forms complexes with DNA, the gene expression was totally suppressed. However, when PKA is being continuously activated, anions were inserted in the polymer by phospholilating the peptides of side chains, the complex of DNA and polymer collapses and transcription of the gene is activated. We attempted to apply this system to living cell, and were successful to intracellular target signal-responsive regulation of delivered gene-expression.

本文言語	英語
ページ数	1
出版ステータス	出版済み - 10 19 2006
イベント	55th SPSJ Annual Meeting - Nagoya, 日本継続期間: 5 24 2006 → 5 26 2006

その他

その他	55th SPSJ Annual Meeting
Country	日本
City	Nagoya
Period	5/24/06 → 5/26/06

All Science Journal Classification (ASJC) codes

Engineering(all)

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引用スタイル

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AU - Oishi, Jun

AU - Kawamura, Kenji

AU - Ijuin, Moeko

AU - Kang, Jeong Hun

AU - Asai, Daisuke

AU - Sato, Yuko

AU - Katayama, Yoshiki

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AB - We recently proposed the novel gene-regulation system responding to cAMP-dependent protein kinase (PKA). For this system, we used the cationic polymer which includes the oligopeptide that is the substrate of PKA. Since this polymer forms complexes with DNA, the gene expression was totally suppressed. However, when PKA is being continuously activated, anions were inserted in the polymer by phospholilating the peptides of side chains, the complex of DNA and polymer collapses and transcription of the gene is activated. We attempted to apply this system to living cell, and were successful to intracellular target signal-responsive regulation of delivered gene-expression.

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