D-RECS (4) a novel gene carrier responding to intracellular protease signal

Kenji Kawamura, Jun Oishi, Moeko Ijuin, Jeong Hun Kang, Daisuke Asai, Yuko Sato, Yoshiki Katayama

研究成果: 会議への寄与タイプ論文

抄録

We recently proposed an artificial gene regulation systems responding to the intracellular protease signal, such as Caspase signal, which is the key signal of the cell death. For this purpose, we designed polymer-peptide conjugate for a gene carrier. This polymer interacts with DNA through an electrostatic interaction and suppressed the gene-transcription. On the other hand, in the presence of active Caspase, this complex is disintegrated and the gene transcription is recovered. In this report, we applied this system to the cell free system and cultured cell, and succeeded in regulating the delivered gene expression responding to the intracellular protease signal.

元の言語英語
ページ数1
出版物ステータス出版済み - 10 19 2006
イベント55th SPSJ Annual Meeting - Nagoya, 日本
継続期間: 5 24 20065 26 2006

その他

その他55th SPSJ Annual Meeting
日本
Nagoya
期間5/24/065/26/06

Fingerprint

Genes
Transcription
Gene expression
Cell death
Polymers
Coulomb interactions
Peptides
DNA
Cells
Peptide Hydrolases

All Science Journal Classification (ASJC) codes

  • Engineering(all)

これを引用

Kawamura, K., Oishi, J., Ijuin, M., Kang, J. H., Asai, D., Sato, Y., & Katayama, Y. (2006). D-RECS (4) a novel gene carrier responding to intracellular protease signal. 論文発表場所 55th SPSJ Annual Meeting, Nagoya, 日本.

D-RECS (4) a novel gene carrier responding to intracellular protease signal. / Kawamura, Kenji; Oishi, Jun; Ijuin, Moeko; Kang, Jeong Hun; Asai, Daisuke; Sato, Yuko; Katayama, Yoshiki.

2006. 論文発表場所 55th SPSJ Annual Meeting, Nagoya, 日本.

研究成果: 会議への寄与タイプ論文

Kawamura, K, Oishi, J, Ijuin, M, Kang, JH, Asai, D, Sato, Y & Katayama, Y 2006, 'D-RECS (4) a novel gene carrier responding to intracellular protease signal', 論文発表場所 55th SPSJ Annual Meeting, Nagoya, 日本, 5/24/06 - 5/26/06.
Kawamura K, Oishi J, Ijuin M, Kang JH, Asai D, Sato Y その他. D-RECS (4) a novel gene carrier responding to intracellular protease signal. 2006. 論文発表場所 55th SPSJ Annual Meeting, Nagoya, 日本.
Kawamura, Kenji ; Oishi, Jun ; Ijuin, Moeko ; Kang, Jeong Hun ; Asai, Daisuke ; Sato, Yuko ; Katayama, Yoshiki. / D-RECS (4) a novel gene carrier responding to intracellular protease signal. 論文発表場所 55th SPSJ Annual Meeting, Nagoya, 日本.1 p.
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AU - Ijuin, Moeko

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AU - Sato, Yuko

AU - Katayama, Yoshiki

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