D-RECS (4) a novel gene carrier responding to intracellular protease signal

Kenji Kawamura, Jun Oishi, Moeko Ijuin, Jeong Hun Kang, Daisuke Asai, Yuko Sato, Yoshiki Katayama

    研究成果: Contribution to conferencePaper査読

    抄録

    We recently proposed an artificial gene regulation systems responding to the intracellular protease signal, such as Caspase signal, which is the key signal of the cell death. For this purpose, we designed polymer-peptide conjugate for a gene carrier. This polymer interacts with DNA through an electrostatic interaction and suppressed the gene-transcription. On the other hand, in the presence of active Caspase, this complex is disintegrated and the gene transcription is recovered. In this report, we applied this system to the cell free system and cultured cell, and succeeded in regulating the delivered gene expression responding to the intracellular protease signal.

    本文言語英語
    ページ数1
    出版ステータス出版済み - 10 19 2006
    イベント55th SPSJ Annual Meeting - Nagoya, 日本
    継続期間: 5 24 20065 26 2006

    その他

    その他55th SPSJ Annual Meeting
    国/地域日本
    CityNagoya
    Period5/24/065/26/06

    All Science Journal Classification (ASJC) codes

    • 工学(全般)

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