DC therapy is now considered to be one of the weapons with which to fight against a variety of cancers. We have investigated the in vivo antitumor effects of intratumoral (i.t.) administration of dendritic cells (DC) following low-dose chemotherapy. Combination of i.t. injection of DC and systemic chemotherapy induced antitumor effects on not only the DC-treated tumor but also on a distant tumor inoculated in the contralateral flank of the animal. To analyze the mechanisms of the systemic antitumor effect induced in this system, we analyzed the cytolytic activity against tumors including injected tumors and others. The cytolytic activity of effector cells from the treated animals was tumor-specific, and was mainly restricted to CD 8 and MHC class I (p<0.01). This study suggests that the strategy of i.t. injection of DC following low-dose chemotherapy could be a powerful weapon to treat patients with cancer in the near future.
|出版ステータス||出版済み - 1 2003|
All Science Journal Classification (ASJC) codes
- Cancer Research