De novo resistance to epidermal growth factor receptor-tyrosine kinase inhibitors in EGFR mutation-positive patients with non-small cell lung cancer

Masayuki Takeda, Isamu Okamoto, Yoshihiko Fujita, Tokuzo Arao, Hiroyuki Ito, Masahiro Fukuoka, Kazuto Nishio, Kazuhiko Nakagawa

研究成果: ジャーナルへの寄稿記事

56 引用 (Scopus)

抄録

Background: Somatic mutations in the epidermal growth factor receptor (EGFR) gene are a predictor of response to treatment with EGFR tyrosine kinase inhibitors (TKIs) in patients with non-small cell lung cancer (NSCLC). However, mechanisms of de novo resistance to these drugs in patients harboring EGFR mutations have remained unclear. We examined whether the mutational status of KRAS might be associated with primary resistance to EGFR-TKIs in EGFR mutation-positive patients with NSCLC. Methods: Forty patients with NSCLC with EGFR mutations who were treated with gefitinib or erlotinib and had archival tissue specimens available were enrolled in the study. KRAS mutations were analyzed by direct sequencing. Results: Three (7.5%) of the 40 patients had progressive disease, and two (67%) of these three individuals had both KRAS and EGFR mutations. Conclusions: Our Results suggest that KRAS mutation is a negative predictor of response to EGFR-TKIs in EGFR mutation-positive patients with NSCLC.

元の言語英語
ページ(範囲)399-400
ページ数2
ジャーナルJournal of Thoracic Oncology
5
発行部数3
DOI
出版物ステータス出版済み - 1 1 2010
外部発表Yes

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Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Mutation
erbB-1 Genes
Drug Resistance

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pulmonary and Respiratory Medicine

これを引用

De novo resistance to epidermal growth factor receptor-tyrosine kinase inhibitors in EGFR mutation-positive patients with non-small cell lung cancer. / Takeda, Masayuki; Okamoto, Isamu; Fujita, Yoshihiko; Arao, Tokuzo; Ito, Hiroyuki; Fukuoka, Masahiro; Nishio, Kazuto; Nakagawa, Kazuhiko.

:: Journal of Thoracic Oncology, 巻 5, 番号 3, 01.01.2010, p. 399-400.

研究成果: ジャーナルへの寄稿記事

Takeda, Masayuki ; Okamoto, Isamu ; Fujita, Yoshihiko ; Arao, Tokuzo ; Ito, Hiroyuki ; Fukuoka, Masahiro ; Nishio, Kazuto ; Nakagawa, Kazuhiko. / De novo resistance to epidermal growth factor receptor-tyrosine kinase inhibitors in EGFR mutation-positive patients with non-small cell lung cancer. :: Journal of Thoracic Oncology. 2010 ; 巻 5, 番号 3. pp. 399-400.
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abstract = "Background: Somatic mutations in the epidermal growth factor receptor (EGFR) gene are a predictor of response to treatment with EGFR tyrosine kinase inhibitors (TKIs) in patients with non-small cell lung cancer (NSCLC). However, mechanisms of de novo resistance to these drugs in patients harboring EGFR mutations have remained unclear. We examined whether the mutational status of KRAS might be associated with primary resistance to EGFR-TKIs in EGFR mutation-positive patients with NSCLC. Methods: Forty patients with NSCLC with EGFR mutations who were treated with gefitinib or erlotinib and had archival tissue specimens available were enrolled in the study. KRAS mutations were analyzed by direct sequencing. Results: Three (7.5{\%}) of the 40 patients had progressive disease, and two (67{\%}) of these three individuals had both KRAS and EGFR mutations. Conclusions: Our Results suggest that KRAS mutation is a negative predictor of response to EGFR-TKIs in EGFR mutation-positive patients with NSCLC.",
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AU - Takeda, Masayuki

AU - Okamoto, Isamu

AU - Fujita, Yoshihiko

AU - Arao, Tokuzo

AU - Ito, Hiroyuki

AU - Fukuoka, Masahiro

AU - Nishio, Kazuto

AU - Nakagawa, Kazuhiko

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