Deafness due to degeneration of cochlear neurons in caspase-3-deficient mice

Hirofumi Morishita, Tomoko Makishima, Chie Kaneko, Yun Shain Lee, Neil Segil, Katsuhiko Takahashi, Akio Kuraoka, Takashi Nakagawa, Junichi Nabekura, Keiko Nakayama, Kei Ichi Nakayama

研究成果: Contribution to journalArticle査読

29 被引用数 (Scopus)

抄録

Mice that lack caspase-3, which functions in apoptosis, were generated by gene targeting and shown to undergo hearing loss. The ABR threshold of the caspase-3-/- mice was significantly elevated compared to that of caspase-3+/+ mice at 15 days of age and was progressively elevated further by 30 days. Distortion product otoacoustic emissions were not detectable in caspase-3-/- mice at 15 days of age. Caspase-3-/- mice exhibited marked degeneration of spiral ganglion neurons and a loss of inner and outer hair cells in the cochlea at 30 days of age, although no such changes were apparent at 15 days. The degenerating neurons manifested features, including cytoplasmic vacuolization, distinct from those characteristic of apoptosis. Spiral ganglion neurons and cochlear hair cells thus appear to require caspase-3 for survival but not for initial development. The mapping of both the human caspase-3 gene and the locus responsible for an autosomal dominant, nonsyndromic form of hearing loss (DFNA24) to chromosome 4q35 suggests that the caspase-3-/- mice may represent a model of this human condition,

本文言語英語
ページ(範囲)142-149
ページ数8
ジャーナルBiochemical and Biophysical Research Communications
284
1
DOI
出版ステータス出版済み - 2001

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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