Death due to asphyxia linked to antipsychotic drugs

N. Jitsufuchi, T. Nagata, K. Kudo, T. Imamura, H. Tokunaga

研究成果: Contribution to journalArticle査読

5 被引用数 (Scopus)


A 46-year-old man with schizophrenia, died in hospital. Autopsy revealed numerous facial injuries and the direct cause of death was apparently asphyxia as a large amount of coagulated blood was present in the lower part of the trachea and bronchi. The blood derived from a lacerated wound of the mouth. The question was raised as to why expectoration was impossible and a toxicological analysis was directed to the antipsychotic drugs allegedly prescribed by doctors at the hospital. Using gas chromatography and gas chromatography/mass spectrometry, four different antipsychotic drugs including chlorpromazine, levomepromazine, zotepine and haloperidol were identified in the whole blood and tissues with concentrations being 1.91, 0.75, 0.61 and 0.48 μg/g in the blood, respectively. These levels were toxic to the extent that he could not expectorate and blood accumulating in the airway led to asphyxia and death.

ジャーナルJapanese Journal of Legal Medicine
出版ステータス出版済み - 1 1 1995

All Science Journal Classification (ASJC) codes

  • 健康政策
  • 法学


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