Decreased CD44H expression in early-stage tongue carcinoma associates with late nodal metastases following interstitial brachytherapy

Muneyuki Masuda, Yuichiro Kuratomi, Hideki Shiratsuchi, Torahiko Nakashima, Kunitake Naonobu, Sohtaro Komiyama

研究成果: Contribution to journalArticle査読

34 被引用数 (Scopus)

抄録

Background. Late nodal metastases is a critical factor that worsens the prognosis of T1/T2N0 tongue cancer treated by interstitial brachytherapy. If we could better predict the patients at high risk for late nodal metastases developing before treatment, more appropriate choices of treatment could be selected. In recent studies of colon cancer, prostate cancer, and laryngeal cancer, CD44H has been postulated to be a metastasis suppressor. Methods. On the basis of this phenomenon, we immunohistochemically evaluated the expression of CD44H in 38 cases of primary T1/T2N0 tongue cancer treated by interstitial brachytherapy. Formalin-fixed, paraffin-embedded biopsy specimens obtained before treatment were examined. Results. The group that had late nodal metastases revealed a significantly lower (p = .0035) CD44H expression. Conclusions. A decreased CD44H expression may therefore be useful as a new predictor of late nodal metastases in patients with T1/T2N0 tongue carcinoma. For patients with a decreased CD44H expression, a partial glossectomy and an elective neck dissection may therefore be an appropriate treatment modality.

本文言語英語
ページ(範囲)662-665
ページ数4
ジャーナルHead and Neck
22
7
DOI
出版ステータス出版済み - 10 2000

All Science Journal Classification (ASJC) codes

  • 耳鼻咽喉科学

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