Decreased expression of calcium-sensing receptor and parafibromin in secondary hyperparathyroidism with an abnormal whole PTH/intact PTH ratio

Shunsuke Yamada, Masanori Tokumoto, Masatomo Taniguchi, Hidehisa Kitada, Kazuhiko Tsuruya, Takanari Kitazono

研究成果: Contribution to journalArticle査読

1 被引用数 (Scopus)

抄録

A 34-year-old female hemodialysis patient with an abnormal whole parathyroid hormone (PTH)/intact PTH ratio (ratio = 1.14) underwent parathyroidectomy for advanced secondary hyperparathyroidism. The abnormal PTH ratio indicated a relative increase in the serum N-terminus PTH, a new molecular form of PTH. The abnormal ratio normalized immediately after the largest parathyroid gland (PTG) was removed, proving the largest PTG as causative. An immunohistochemical analysis revealed extremely decreased expression of the calcium-sensing receptor and parafibromin in the largest PTG in comparison with the other PTGs. This case indicated the possible involvement of decreased calcium-sensing receptor and parafibromin signaling in the development of the abnormal PTH ratio.

本文言語英語
ページ(範囲)429-432
ページ数4
ジャーナルClinical Kidney Journal
6
4
DOI
出版ステータス出版済み - 8 2013

All Science Journal Classification (ASJC) codes

  • 腎臓病学
  • 移植

フィンガープリント

「Decreased expression of calcium-sensing receptor and parafibromin in secondary hyperparathyroidism with an abnormal whole PTH/intact PTH ratio」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル