Decreased expression of interleukin-21 receptor on peripheral B lymphocytes in systemic lupus erythematosus.

Hiroki Mitoma, Takahiko Horiuchi, yasutaka kimoto, Hiroshi Tsukamoto, Ayumi Uchino, Yasuhiro Tamimoto, Yugo Miyagi, Mine Harada

研究成果: ジャーナルへの寄稿記事

40 引用 (Scopus)

抄録

Interleukin-21 (IL-21) is the most recent member of the common gamma-chain-dependent cytokine family. We studied the expression of the IL-21 receptor (IL-21R) on peripheral B lymphocytes in patients with systemic lupus erythematosus (SLE) or primary Sjögren's syndrome (pSjS), and healthy controls. Naive B lymphocytes expressed higher levels of IL-21R than memory B lymphocytes and plasmablasts, both in SLE patients and healthy controls. The proportion of IL-21R+ cells in the total peripheral B lymphocytes, as well as those in the respective B lymphocyte subsets, was significantly lower in SLE compared with those of pSjS or healthy controls (p=0.0002 and p<0.0001, respectively, in total B lymphocytes). The decreased expression of IL-21R in SLE was significantly associated with nephritis and high titer anti-double-strand DNA antibody. In some SLE patients, IL-21-induced proliferation of CD19+ B lymphocytes, in the presence of CD40 stimulation, was impaired. The abnormalities of IL-21R signaling might contribute to the pathological features of SLE, such as B lymphocytopenia.

元の言語英語
ページ(範囲)609-615
ページ数7
ジャーナルInternational journal of molecular medicine
16
発行部数4
出版物ステータス出版済み - 1 1 2005

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Interleukin-21 Receptors
Systemic Lupus Erythematosus
B-Lymphocytes
B-Lymphocyte Subsets
Lymphopenia
Nephritis
Cytokines
Antibodies
DNA

All Science Journal Classification (ASJC) codes

  • Genetics

これを引用

Decreased expression of interleukin-21 receptor on peripheral B lymphocytes in systemic lupus erythematosus. / Mitoma, Hiroki; Horiuchi, Takahiko; kimoto, yasutaka; Tsukamoto, Hiroshi; Uchino, Ayumi; Tamimoto, Yasuhiro; Miyagi, Yugo; Harada, Mine.

:: International journal of molecular medicine, 巻 16, 番号 4, 01.01.2005, p. 609-615.

研究成果: ジャーナルへの寄稿記事

Mitoma, Hiroki ; Horiuchi, Takahiko ; kimoto, yasutaka ; Tsukamoto, Hiroshi ; Uchino, Ayumi ; Tamimoto, Yasuhiro ; Miyagi, Yugo ; Harada, Mine. / Decreased expression of interleukin-21 receptor on peripheral B lymphocytes in systemic lupus erythematosus. :: International journal of molecular medicine. 2005 ; 巻 16, 番号 4. pp. 609-615.
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abstract = "Interleukin-21 (IL-21) is the most recent member of the common gamma-chain-dependent cytokine family. We studied the expression of the IL-21 receptor (IL-21R) on peripheral B lymphocytes in patients with systemic lupus erythematosus (SLE) or primary Sj{\"o}gren's syndrome (pSjS), and healthy controls. Naive B lymphocytes expressed higher levels of IL-21R than memory B lymphocytes and plasmablasts, both in SLE patients and healthy controls. The proportion of IL-21R+ cells in the total peripheral B lymphocytes, as well as those in the respective B lymphocyte subsets, was significantly lower in SLE compared with those of pSjS or healthy controls (p=0.0002 and p<0.0001, respectively, in total B lymphocytes). The decreased expression of IL-21R in SLE was significantly associated with nephritis and high titer anti-double-strand DNA antibody. In some SLE patients, IL-21-induced proliferation of CD19+ B lymphocytes, in the presence of CD40 stimulation, was impaired. The abnormalities of IL-21R signaling might contribute to the pathological features of SLE, such as B lymphocytopenia.",
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AU - Mitoma, Hiroki

AU - Horiuchi, Takahiko

AU - kimoto, yasutaka

AU - Tsukamoto, Hiroshi

AU - Uchino, Ayumi

AU - Tamimoto, Yasuhiro

AU - Miyagi, Yugo

AU - Harada, Mine

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N2 - Interleukin-21 (IL-21) is the most recent member of the common gamma-chain-dependent cytokine family. We studied the expression of the IL-21 receptor (IL-21R) on peripheral B lymphocytes in patients with systemic lupus erythematosus (SLE) or primary Sjögren's syndrome (pSjS), and healthy controls. Naive B lymphocytes expressed higher levels of IL-21R than memory B lymphocytes and plasmablasts, both in SLE patients and healthy controls. The proportion of IL-21R+ cells in the total peripheral B lymphocytes, as well as those in the respective B lymphocyte subsets, was significantly lower in SLE compared with those of pSjS or healthy controls (p=0.0002 and p<0.0001, respectively, in total B lymphocytes). The decreased expression of IL-21R in SLE was significantly associated with nephritis and high titer anti-double-strand DNA antibody. In some SLE patients, IL-21-induced proliferation of CD19+ B lymphocytes, in the presence of CD40 stimulation, was impaired. The abnormalities of IL-21R signaling might contribute to the pathological features of SLE, such as B lymphocytopenia.

AB - Interleukin-21 (IL-21) is the most recent member of the common gamma-chain-dependent cytokine family. We studied the expression of the IL-21 receptor (IL-21R) on peripheral B lymphocytes in patients with systemic lupus erythematosus (SLE) or primary Sjögren's syndrome (pSjS), and healthy controls. Naive B lymphocytes expressed higher levels of IL-21R than memory B lymphocytes and plasmablasts, both in SLE patients and healthy controls. The proportion of IL-21R+ cells in the total peripheral B lymphocytes, as well as those in the respective B lymphocyte subsets, was significantly lower in SLE compared with those of pSjS or healthy controls (p=0.0002 and p<0.0001, respectively, in total B lymphocytes). The decreased expression of IL-21R in SLE was significantly associated with nephritis and high titer anti-double-strand DNA antibody. In some SLE patients, IL-21-induced proliferation of CD19+ B lymphocytes, in the presence of CD40 stimulation, was impaired. The abnormalities of IL-21R signaling might contribute to the pathological features of SLE, such as B lymphocytopenia.

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