Decreased Skeletal Muscle Vasodilation in Patients with Congestive Heart Failure

Tsutomu Imaizumi, Yoshitake Hirooka, Akira Takeshita, Tsutomu Imaizumi

    研究成果: Contribution to journalArticle査読

    7 被引用数 (Scopus)

    抄録

    In congestive heart failure (CHF), excessive vasoconstriction is present, which is due to overactive vasoconstrictor mechanisms although vasodilator mechanisms may be impaired. In the present study, we examined vasodilation in CHF by measuring forearm blood flow with a strain gauge plethysmograph. Patients with CHF had higher forearm vascular resistance than normal control subjects. Patients with CHF had decreased forearm vasodilation in response to intra-arterial infusions of atrial natriuretic peptide (ANP) and acetylcholine, but not in response to sodium nitroprusside or nitroglycerin. Oral captopril did not alter the degree of forearm vasodilation during handgrip exercise. These results suggest that endothelium-dependent and ANP-induced forearm vasodilation is impaired in patients with CHF but the decreased vasodilation is not due to impaired vascular smooth muscle responsiveness to a vasodilator. The renin-angiotensin system does not seem to play a major role in the maintenance of vascular resistance during exercise in CHF.

    本文言語英語
    ページ(範囲)500-503
    ページ数4
    ジャーナルJAPANESE CIRCULATION JOURNAL
    56
    5
    DOI
    出版ステータス出版済み - 1992

    All Science Journal Classification (ASJC) codes

    • 生理学
    • 循環器および心血管医学

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