Decreased stimulus-driven connectivity of the primary visual cortex during visual motion stimulation in amnestic mild cognitive impairment: An fMRI study

Takao Yamasaki, Toshihiko Aso, Yumiko Kaseda, Yasuyo Mimori, Hikaru Doi, Naoki Matsuoka, Naomi Takamiya, Tsuyoshi Torii, Tetsuya Takahashi, Tomohiko Ohshita, Hiroshi Yamashita, Hitoka Doi, Saeko Inamizu, Hiroshi Chatani, Shozo Tobimatsu

研究成果: ジャーナルへの寄稿記事

抄録

Motion perceptual deficits are common in Alzheimer's disease (AD). Although the posterior parietal cortex is thought to play a critical role in these deficits, it is currently unclear whether the primary visual cortex (V1) contributes to these deficits in AD. To elucidate this issue, we investigated the net activity or connectivity within V1 in 17 amnestic mild cognitive impairment (aMCI) patients, 17 AD patients and 17 normal controls (NC) using functional magnetic resonance imaging (fMRI). fMRI was recorded under two conditions: visual motion stimulation and resting-state. The net activity or connectivity within V1 extracted by independent component analysis (ICA) was significantly increased during visual motion stimuli compared with that of the resting-state condition in NC, but not in aMCI or AD patients. These findings suggest the alteration of the net activity or connectivity within V1, which may contribute to the previously reported motion perceptual deficits in aMCI and AD. Therefore, the decreased net V1 activity measured as the strength of the ICA component may provide a new disease biomarker for early detection of AD.

元の言語英語
記事番号134402
ジャーナルNeuroscience Letters
711
DOI
出版物ステータス出版済み - 10 15 2019

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Photic Stimulation
Visual Cortex
Alzheimer Disease
Magnetic Resonance Imaging
Parietal Lobe
Cognitive Dysfunction
Early Diagnosis
Biomarkers

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

これを引用

Decreased stimulus-driven connectivity of the primary visual cortex during visual motion stimulation in amnestic mild cognitive impairment : An fMRI study. / Yamasaki, Takao; Aso, Toshihiko; Kaseda, Yumiko; Mimori, Yasuyo; Doi, Hikaru; Matsuoka, Naoki; Takamiya, Naomi; Torii, Tsuyoshi; Takahashi, Tetsuya; Ohshita, Tomohiko; Yamashita, Hiroshi; Doi, Hitoka; Inamizu, Saeko; Chatani, Hiroshi; Tobimatsu, Shozo.

:: Neuroscience Letters, 巻 711, 134402, 15.10.2019.

研究成果: ジャーナルへの寄稿記事

Yamasaki, T, Aso, T, Kaseda, Y, Mimori, Y, Doi, H, Matsuoka, N, Takamiya, N, Torii, T, Takahashi, T, Ohshita, T, Yamashita, H, Doi, H, Inamizu, S, Chatani, H & Tobimatsu, S 2019, 'Decreased stimulus-driven connectivity of the primary visual cortex during visual motion stimulation in amnestic mild cognitive impairment: An fMRI study', Neuroscience Letters, 巻. 711, 134402. https://doi.org/10.1016/j.neulet.2019.134402
Yamasaki, Takao ; Aso, Toshihiko ; Kaseda, Yumiko ; Mimori, Yasuyo ; Doi, Hikaru ; Matsuoka, Naoki ; Takamiya, Naomi ; Torii, Tsuyoshi ; Takahashi, Tetsuya ; Ohshita, Tomohiko ; Yamashita, Hiroshi ; Doi, Hitoka ; Inamizu, Saeko ; Chatani, Hiroshi ; Tobimatsu, Shozo. / Decreased stimulus-driven connectivity of the primary visual cortex during visual motion stimulation in amnestic mild cognitive impairment : An fMRI study. :: Neuroscience Letters. 2019 ; 巻 711.
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