Decreases in pheromonal responses at the accessory olfactory bulb of mice with a deficiency of the α1B or β3 subunits of voltage-dependent Ca2+-channels

Manabu Murakami, Hitosi Matsui, Takeshi Shiraiwa, Takashi Suzuki, Hironobu Sasano, Eiki Takahashi, Makoto Kashiwayanagi

研究成果: Contribution to journalArticle査読

5 被引用数 (Scopus)

抄録

Pheromones affect gonadal functions and sexual behaviors. Information in regard to pheromones is received by the vomeronasal organ (VNO) and transmitted to the accessory olfactory bulb (AOB). We investigated the physiological role of the α1B and β3 subunits of the N (neuronal)-type voltage-dependent Ca2+ channel in the neurotransduction in the accessory olfactory (vomeronasal) system using α1B-deficient mice and β3-deficient mice. RT-PCR studies showed the existence of β1, β2, β3, β4, α1A, α1B, and α1C subunits of voltage-dependent Ca2+ channels in the mouse VNO. Immunohistochemical studies showed that the α1A, α1B, and α1C subunits of voltage-dependent Ca2+ channels exist in the sensory neurons and supporting cells of the mouse VNO. Exposure of the VNO to urine samples excreted from male mice induced lower Fos-immunoreactivity in the periglomerular (PG) cells of the AOBs in α1B-deficient female mice than in those of wild mice. The density of Fos-immunoreactive (Fos-ir) cells after exposure to female urine samples at the periglomerular cell layer of α1B-deficient male mice was lower than that of wild mice. Exposure of the VNO of β3-deficient female mice to male urine samples also induced low Fos-ir cells in the periglomerular cell layer of the AOB. These data suggest the importance of the α1B and β3 subunits of the N-type voltage-dependent Ca2+ channel for the pheromone signal transduction system.

本文言語英語
ページ(範囲)437-442
ページ数6
ジャーナルBiological and Pharmaceutical Bulletin
29
3
DOI
出版ステータス出版済み - 3 2006
外部発表はい

All Science Journal Classification (ASJC) codes

  • 薬理学
  • 薬科学

フィンガープリント

「Decreases in pheromonal responses at the accessory olfactory bulb of mice with a deficiency of the α<sub>1B</sub> or β3 subunits of voltage-dependent Ca<sup>2+</sup>-channels」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル