Dedifferentiated low-grade central osteosarcoma with extensive cystic change initially treated as a simple bone cyst

Masakazu Toya, Yuichi Yamada, Ryohei Yokoyama, Kenichi Taguchi, Kazuki Nabeshima, Teruto Isayama, Yoshinao Oda

研究成果: Contribution to journalArticle査読

抄録

Low-grade central osteosarcoma (LG-COS) is an uncommon variant of osteosarcoma (OS) that sometimes progresses to high-grade OS post-recurrence. We herein present a case of dedifferentiated LG-COS with extensive cystic change arising in the right iliac bone of a 26-year-old man. The LG-COS was initially diagnosed and managed as a simple bone cyst. The lesion recurred thrice, and high-grade OS was diagnosed during the third recurrence. The first lesion appeared as a typical benign cystic mass on radiography. However, a huge malignant osteoblastic mass subsequently developed in the right pelvis at the third recurrence. Extended hemipelvectomy with ipsilateral hemisacral resection was performed. Histologic analysis showed tumor necrosis and irregular neoplastic tumor osteoid, while immunohistochemistry revealed that the tumor was diffusely positive for MDM2 and CDK4. The histologic diagnosis was high-grade OS dedifferentiated from a preceding cystic lesion. Our final diagnosis of the primary lesion was LG-COS with extensive cystic change.

本文言語英語
論文番号152832
ジャーナルPathology Research and Practice
216
4
DOI
出版ステータス出版済み - 4 2020

All Science Journal Classification (ASJC) codes

  • 病理学および法医学
  • 細胞生物学

フィンガープリント

「Dedifferentiated low-grade central osteosarcoma with extensive cystic change initially treated as a simple bone cyst」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル