Deduced primary structure of rat tryptophan-2,3-dioxygenase

Katsumi Maezono, Kosuke Tashiro, Toshikazu Nakamura

研究成果: Contribution to journalArticle査読

30 被引用数 (Scopus)

抄録

The complete amino acid sequence of the tryptophan 2, 3-dioxygenase (TO) of rat liver was determined from the nucleotide sequence of a full length TO cDNA isolated from a rat liver cDNA library and determined its primary structure. TO was encoded in a mRNA of about 1.7 kb containing an open reading frame of 1218 bp. According to the deduced amino acid sequence, the monomeric polypeptide of TO consisted of 406 amino acid residues with a calculated molecular weight of 47,796 daltons. It has twelve histidine residues around its hydrophobic region, which has homology with some heme proteins and oxygenase, suggesting that this hydrophobic region might to be the core of TO for the activity.

本文言語英語
ページ(範囲)176-181
ページ数6
ジャーナルBiochemical and Biophysical Research Communications
170
1
DOI
出版ステータス出版済み - 7 16 1990

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

フィンガープリント

「Deduced primary structure of rat tryptophan-2,3-dioxygenase」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル