Deduced primary structure of rat tryptophan-2,3-dioxygenase

Katsumi Maezono, Kosuke Tashiro, Toshikazu Nakamura

研究成果: ジャーナルへの寄稿記事

30 引用 (Scopus)

抄録

The complete amino acid sequence of the tryptophan 2, 3-dioxygenase (TO) of rat liver was determined from the nucleotide sequence of a full length TO cDNA isolated from a rat liver cDNA library and determined its primary structure. TO was encoded in a mRNA of about 1.7 kb containing an open reading frame of 1218 bp. According to the deduced amino acid sequence, the monomeric polypeptide of TO consisted of 406 amino acid residues with a calculated molecular weight of 47,796 daltons. It has twelve histidine residues around its hydrophobic region, which has homology with some heme proteins and oxygenase, suggesting that this hydrophobic region might to be the core of TO for the activity.

元の言語英語
ページ(範囲)176-181
ページ数6
ジャーナルBiochemical and Biophysical Research Communications
170
発行部数1
DOI
出版物ステータス出版済み - 7 16 1990

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Tryptophan Oxygenase
Rats
Amino Acid Sequence
Hemeproteins
Amino Acids
Heme Oxygenase (Decyclizing)
Liver
Gene Library
Histidine
Open Reading Frames
Complementary DNA
Molecular Weight
Messenger RNA
Peptides
Nucleotides
Molecular weight

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

これを引用

Deduced primary structure of rat tryptophan-2,3-dioxygenase. / Maezono, Katsumi; Tashiro, Kosuke; Nakamura, Toshikazu.

:: Biochemical and Biophysical Research Communications, 巻 170, 番号 1, 16.07.1990, p. 176-181.

研究成果: ジャーナルへの寄稿記事

Maezono, Katsumi ; Tashiro, Kosuke ; Nakamura, Toshikazu. / Deduced primary structure of rat tryptophan-2,3-dioxygenase. :: Biochemical and Biophysical Research Communications. 1990 ; 巻 170, 番号 1. pp. 176-181.
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