Deep and future insights into neuromodulation therapies for heart failure

Takuya Kishi

    研究成果: Contribution to journalReview article査読

    3 被引用数 (Scopus)

    抄録

    Major pathophysiology of heart failure is an autonomic nervous system dysfunction as a result of excess sympathoexcitation and/or withdrawal of vagal nerve activity. Although we already have various pharmacological and non-pharmacological therapies for heart failure, survival of heart failure patients remains around 50%. To achieve further reductions in morbidity and mortality of heart failure, neuromodulations with devices, such as baroreflex activating therapy, vagal nerve stimulation, renal sympathetic denervation, spinal cord stimulation, and left cardiac sympathetic denervation, have been expected. Although all of these neuromodulations have benefits on heart failure, efficacy, and safety in preclinical and small-sized clinical studies, the benefits on heart failure have been insufficient and controversial compared to our expectations in large-sized randomized trials. However, we should develop and apply these novel therapies for the patients with heart failure in the near future.

    本文言語英語
    ページ(範囲)368-372
    ページ数5
    ジャーナルJournal of Cardiology
    68
    5
    DOI
    出版ステータス出版済み - 11 1 2016

    All Science Journal Classification (ASJC) codes

    • Cardiology and Cardiovascular Medicine

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