Deep eutectic solvent as a novel disperser in dispersive liquid-liquid microextraction based on solidification of floating organic droplet (DLLME-SFOD) for preconcentration of steroids in water samples: Assessment of the method deleterious impact on the environment using Analytical Eco-Scale and Green Analytical Procedure Index

Asmaa Kamal El-Deen, Kuniyoshi Shimizu

研究成果: ジャーナルへの寄稿記事

抄録

Herein, we seek clues to investigate the effectiveness of deep eutectic solvent (DES) as a novel dispersive solvent in DLLME-SFOD for the enrichment of nine steroids in water for the first time. The novel DLLME-SFOD method is premised on using 2-dodecanol as extractant and DES (tetrabutylammonium bromide: acetic acid) as a dispersive solvent. Using DES as disperser was compared with other conventional dispersers like (ethanol, methanol, and acetone) attaining a higher recovery than the conventional dispersers. Both HPLC-DAD separation and DLLME-SFOD procedure were optimized by one-factor-at-a-time (OFAT) succeeded by experimental design applying response surface methodology (RSM) to check the optimal conditions of both HPLC separation and extraction. Under the optimal conditions, the proposed method revealed good linearity (correlation coefficients ≥0.998), low detection limits (in the range of 1.0–9.7 ng/mL), and high inter- and intra-day precision (%RSD <5) with high preconcentration factors in the ranges of (44–112) for the nine concerned steroids. Moreover, the method was successfully applied to determine the concerned steroids in different real aqueous samples with expanded measurement uncertainty of the results <17% at 95% confidence level. Finally, the developed procedure impact on the environment was assessed by applying the Analytical Eco-Scale and Green Analytical Procedure Index (GAPI) tools, proving the greenness of the method. The novel disperser DESs have the merits of simple preparation, low cost, enhancing extraction efficiency and being eco-friendly. These DESs can be used to replace conventional organic disperser solvents.

元の言語英語
記事番号103988
ジャーナルMicrochemical Journal
149
DOI
出版物ステータス出版済み - 9 1 2019

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Eutectics
Solidification
Steroids
Water
Liquids
Dodecanol
Acetone
Acetic Acid
Design of experiments
Organic solvents
Methanol
Ethanol
Recovery
Costs

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Spectroscopy

これを引用

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title = "Deep eutectic solvent as a novel disperser in dispersive liquid-liquid microextraction based on solidification of floating organic droplet (DLLME-SFOD) for preconcentration of steroids in water samples: Assessment of the method deleterious impact on the environment using Analytical Eco-Scale and Green Analytical Procedure Index",
abstract = "Herein, we seek clues to investigate the effectiveness of deep eutectic solvent (DES) as a novel dispersive solvent in DLLME-SFOD for the enrichment of nine steroids in water for the first time. The novel DLLME-SFOD method is premised on using 2-dodecanol as extractant and DES (tetrabutylammonium bromide: acetic acid) as a dispersive solvent. Using DES as disperser was compared with other conventional dispersers like (ethanol, methanol, and acetone) attaining a higher recovery than the conventional dispersers. Both HPLC-DAD separation and DLLME-SFOD procedure were optimized by one-factor-at-a-time (OFAT) succeeded by experimental design applying response surface methodology (RSM) to check the optimal conditions of both HPLC separation and extraction. Under the optimal conditions, the proposed method revealed good linearity (correlation coefficients ≥0.998), low detection limits (in the range of 1.0–9.7 ng/mL), and high inter- and intra-day precision ({\%}RSD <5) with high preconcentration factors in the ranges of (44–112) for the nine concerned steroids. Moreover, the method was successfully applied to determine the concerned steroids in different real aqueous samples with expanded measurement uncertainty of the results <17{\%} at 95{\%} confidence level. Finally, the developed procedure impact on the environment was assessed by applying the Analytical Eco-Scale and Green Analytical Procedure Index (GAPI) tools, proving the greenness of the method. The novel disperser DESs have the merits of simple preparation, low cost, enhancing extraction efficiency and being eco-friendly. These DESs can be used to replace conventional organic disperser solvents.",
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