Defecation frequency and glycemic control in patients with diabetes: The Fukuoka Diabetes Registry

Toshiaki Ohkuma, Masanori Iwase, Hiroki Fujii, Hitoshi Ide, Yuji Komorita, Masahito Yoshinari, Yutaro Oku, Taiki Higashi, Udai Nakamura, Takanari Kitazono

研究成果: Contribution to journalArticle査読

1 被引用数 (Scopus)

抄録

Aims: Constipation has been shown to be associated with a higher risk of diabetes. However, few studies have evaluated the relationship between defecation frequency, one of the major symptoms of constipation, and glycemic control in patients with diabetes. The aim of the present study was to determine the relationship between defecation frequency and HbA1c in patients with diabetes. Methods: We determined the relationship between defecation frequency and HbA1c in 5029 patients with diabetes in the Fukuoka Diabetes Registry, a multi-center prospective cohort study conducted in diabetes specialist outpatient clinic (mean age 64.9 years, men 55%). Participants were classified according to their defecation frequency: ≥7, 3–<7 and <3 times/week. Results: Low defecation frequency was linearly associated with high HbA1c, with mean levels of 7.41% (95% confidence interval, 7.37–7.44%), 7.54% (7.49–7.60%) and 7.63% (7.52–7.74%) for patients with defecation frequencies of ≥7 times/week, 3–<7 times/week and <3 times/week (p for trend <0.001). This association remained after multivariable adjustment for confounding factors. There was no evidence of heterogeneity in the association between defecation frequency and HbA1c level according to age, sex, type of diabetes, or laxative use. Conclusions: The present study suggests the importance of assessing defecation frequency in the management of diabetes.

本文言語英語
論文番号107751
ジャーナルJournal of Diabetes and Its Complications
35
2
DOI
出版ステータス出版済み - 2 2021

All Science Journal Classification (ASJC) codes

  • 内科学
  • 内分泌学、糖尿病および代謝内科学
  • 内分泌学

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