TY - JOUR
T1 - Defecation frequency and glycemic control in patients with diabetes
T2 - The Fukuoka Diabetes Registry
AU - Ohkuma, Toshiaki
AU - Iwase, Masanori
AU - Fujii, Hiroki
AU - Ide, Hitoshi
AU - Komorita, Yuji
AU - Yoshinari, Masahito
AU - Oku, Yutaro
AU - Higashi, Taiki
AU - Nakamura, Udai
AU - Kitazono, Takanari
N1 - Funding Information:
The Japan Society for the Promotion of Science KAKENHI from the Ministry of Education, Culture, Sports, Science and Technology of Japan (grant numbers 19K24229 to T.O., 23249037 and 23659353 to M.I., and 16K00861 to H.F.), the Junior Scientist Development Grant from the Japan Diabetes Society (to T.O and Y.K.), a grant from the Japan Diabetes Foundation (to T.O.), the Japan Heart Foundation and Astellas / Pfizer Grant for Research on Atherosclerosis Update (to T.O.) and a Lilly Research Grant for Bone and Mineral Research (to Y.K.).
Funding Information:
The authors thank Drs Toshiharu Ninomiya, Dongchon Kang, Shuzo Kumagai, Yoichiro Hirakawa, Shinako Kaizu-Ogata, Akiko Sumi, Tamaki Jodai-Kitamura, Ai Murao-Kimura (Kyushu University), Nobutaka Tsutsu, Nobuhiro Sasaki (Fukuoka Red Cross Hospital), Kiyohide Nunoi, Yuichi Sato, Yuji Uchizono, Kaori Itoh (St. Mary's Hospital), Hirofumi Imoto (Steel Memorial Yawata Hospital), Daisuke Gotoh (Kyushu Central Hospital), Sakae Nohara, Ayako Tsutsumi (Fukuoka Higashi Medical Center), Yasuhiro Idewaki (Hakujyuji Hospital), Masae Minami (Clinic Minami Masae), Miya Wada (Wada Miya Naika Clinic), Yoshifumi Yokomizo (Yokomizo Naika Clinic), Masanori Kikuchi, Yohei Kikuchi (Kikuchi Naika Clinic), Riku Nomiyama (Suzuki Naika Clinic), Shin Nakamura (Nakamura Naika Clinic), Kenji Tashiro (Oshima Eye Hospital), Mototaka Yoshinari (Yoshinari Naika Clinic), Kojiro Ichikawa (Fukutsu Naika Clinic), and Yutaka Kiyohara and Teruo Omae (Hisayama Research Institute For Lifestyle Diseases). The authors also thank the clinical research coordinators, Chiho Ohba (Hisayama Research Institute For Lifestyle Diseases) and Kayoko Sekioka, Yoko Nishioka (Kyushu University), and those in the administration office, Tomoko Matake (Hisayama Research Institute For Lifestyle Diseases) and Junko Ishimatsu (Kyushu University). We thank Mark Cleasby, PhD, from Edanz Group (www.edanzediting.com/ac) for editing a draft of this manuscript. The Japan Society for the Promotion of Science KAKENHI from the Ministry of Education, Culture, Sports, Science and Technology of Japan (grant numbers 19K24229 to T.O. 23249037 and 23659353 to M.I. and 16K00861 to H.F.), the Junior Scientist Development Grant from the Japan Diabetes Society (to T.O and Y.K.), a grant from the Japan Diabetes Foundation (to T.O.), the Japan Heart Foundation and Astellas/Pfizer Grant for Research on Atherosclerosis Update (to T.O.) and a Lilly Research Grant for Bone and Mineral Research (to Y.K.).
Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2021/2
Y1 - 2021/2
N2 - Aims: Constipation has been shown to be associated with a higher risk of diabetes. However, few studies have evaluated the relationship between defecation frequency, one of the major symptoms of constipation, and glycemic control in patients with diabetes. The aim of the present study was to determine the relationship between defecation frequency and HbA1c in patients with diabetes. Methods: We determined the relationship between defecation frequency and HbA1c in 5029 patients with diabetes in the Fukuoka Diabetes Registry, a multi-center prospective cohort study conducted in diabetes specialist outpatient clinic (mean age 64.9 years, men 55%). Participants were classified according to their defecation frequency: ≥7, 3–<7 and <3 times/week. Results: Low defecation frequency was linearly associated with high HbA1c, with mean levels of 7.41% (95% confidence interval, 7.37–7.44%), 7.54% (7.49–7.60%) and 7.63% (7.52–7.74%) for patients with defecation frequencies of ≥7 times/week, 3–<7 times/week and <3 times/week (p for trend <0.001). This association remained after multivariable adjustment for confounding factors. There was no evidence of heterogeneity in the association between defecation frequency and HbA1c level according to age, sex, type of diabetes, or laxative use. Conclusions: The present study suggests the importance of assessing defecation frequency in the management of diabetes.
AB - Aims: Constipation has been shown to be associated with a higher risk of diabetes. However, few studies have evaluated the relationship between defecation frequency, one of the major symptoms of constipation, and glycemic control in patients with diabetes. The aim of the present study was to determine the relationship between defecation frequency and HbA1c in patients with diabetes. Methods: We determined the relationship between defecation frequency and HbA1c in 5029 patients with diabetes in the Fukuoka Diabetes Registry, a multi-center prospective cohort study conducted in diabetes specialist outpatient clinic (mean age 64.9 years, men 55%). Participants were classified according to their defecation frequency: ≥7, 3–<7 and <3 times/week. Results: Low defecation frequency was linearly associated with high HbA1c, with mean levels of 7.41% (95% confidence interval, 7.37–7.44%), 7.54% (7.49–7.60%) and 7.63% (7.52–7.74%) for patients with defecation frequencies of ≥7 times/week, 3–<7 times/week and <3 times/week (p for trend <0.001). This association remained after multivariable adjustment for confounding factors. There was no evidence of heterogeneity in the association between defecation frequency and HbA1c level according to age, sex, type of diabetes, or laxative use. Conclusions: The present study suggests the importance of assessing defecation frequency in the management of diabetes.
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UR - http://www.scopus.com/inward/citedby.url?scp=85094587158&partnerID=8YFLogxK
U2 - 10.1016/j.jdiacomp.2020.107751
DO - 10.1016/j.jdiacomp.2020.107751
M3 - Article
C2 - 33127269
AN - SCOPUS:85094587158
VL - 35
JO - Journal of Diabetes and its Complications
JF - Journal of Diabetes and its Complications
SN - 1056-8727
IS - 2
M1 - 107751
ER -
