Definitive hematopoiesis from endothelial cells in the mouse embryo; a simple guide

Daisuke Sugiyama, Kohichiro Tsuji

研究成果: Contribution to journalReview article査読

21 被引用数 (Scopus)

抄録

Circulation is composed of two interactive systems, the cardiovascular and the hematopoietic, which affect each other. Recently, endothelial progenitor cells/angioblasts have been identified in the circulation of the adult mouse and human. Furthermore, some hematopoietic cells (HCs) have been shown to contribute to angiogenesis, suggesting that HCs can transdifferentiate into endothelial cells (ECs). Although these concepts in adult are still controversial, understanding the mechanisms of the relationship between ECs and HCs would benefit the clinical application for cardiovascular and hematologic disorders. Both ECs and HCs are considered to be derived from a common germ layer, the mesoderm, and have more intimate relationship in embryo than in adult. Here, we describe the relationship between ECs and HCs with special attention to the hemogenic ECs in the mouse embryo.

本文言語英語
ページ(範囲)45-49
ページ数5
ジャーナルTrends in Cardiovascular Medicine
16
2
DOI
出版ステータス出版済み - 2 2006
外部発表はい

All Science Journal Classification (ASJC) codes

  • 循環器および心血管医学

フィンガープリント

「Definitive hematopoiesis from endothelial cells in the mouse embryo; a simple guide」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル