Delay in expression of a mammary tumor provirus is responsible for defective clonal deletion during postnatal period

Naoya Niimi, Shin Tomida, Minoru Ueda, Toshio Kaneda, Yoshihiro Ando, Makoto Takeuchi, Yasunobu Yoshikai, Worawidh Wajjwalku

研究成果: Contribution to journalArticle査読

6 被引用数 (Scopus)

抄録

A gene‐encoding ligand for deletion of T cells bearing TcRVβ6 and Vβ8.1 cosegregates a new mammary tumor provirus locus, Mtv‐50 in NC mice. The sequence of the open reading frame (ORF) in the 3′ long terminal repeat (LTR) of Mtv‐50 was strikingly similar to those of Mtv‐7, Mtv‐43 and exogenous mouse mammary tumor virus (SW) with properties of minor lymphocyte stimulating antigen 1a. Consistent with previous reports, clonal deletion of mature thymocytes bearing TcRVβ6 was defective during the early postnatal period of mice carrying Mtv‐50. Appreciable levels of mRNA corresponding to common Mtv ORF and Mtv‐6 ORF were expressed in the neonatal thymus, while little, if any, mRNA corresponding to Mtv‐50 ORF was detected in the thymus at the early postnatal stage. Delay in expression of Mtv‐50 ORF during the postnatal period may be responsible for the failure of clonal deletion of Vβ6‐T cells in the early postnatal life of mice carrying Mtv‐50.

本文言語英語
ページ(範囲)488-491
ページ数4
ジャーナルEuropean Journal of Immunology
24
2
DOI
出版ステータス出版済み - 2 1994
外部発表はい

All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • 免疫学

フィンガープリント

「Delay in expression of a mammary tumor provirus is responsible for defective clonal deletion during postnatal period」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル