Delayed type skin response to myelin basic protein in chronic relapsing experimental allergic encephalomyelitis

Takeshi Tabira, Yasuto Itoyama, Yoshigoro Kuroiwa, Chiharu Kubo, Yoshitaka Nagai

研究成果: Contribution to journalArticle査読

8 被引用数 (Scopus)

抄録

The skin response to myelin basic protein (MBP) was studied in chronic relapsing experimental allergic encephalomyelitis (EAE) using strain 13 guinea pigs. The delayed type skin response showed a monophasic curve; it gradually increased after immunization, reached maximum levels around 80 days post-immunization, and decreased thereafter. Relapses were more frequent while it was at high levels although it did not correlate directly in individuals with the clinical stage. The skin response was also high in MBP-immunized animals which had recovered from acute EAE. Our results suggest that delayed type hypersensitivity to MBP is involved but is not sufficient by itself to cause relapsing EAE.

本文言語英語
ページ(範囲)295-304
ページ数10
ジャーナルJournal of Neuroimmunology
5
3
DOI
出版ステータス出版済み - 12 1983

All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • 免疫学
  • 神経学
  • 臨床神経学

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