Delphinidin-3-glucoside suppresses lipid accumulation in HepG2 cells

Gakuro Harada, Shiori Onoue, Chisato Inoue, Sakae Hanada, Yoshinori Katakura

研究成果: ジャーナルへの寄稿記事

抄録

Delphinidin is an anthocyanidin commonly found in various fruits and vegetables. Delphinidin has been known to possess many functions, such as an antioxidant, and anti-inflammatory, anti-cancer and anti-muscular atrophy agent. In this study, we attempted to evaluate the effects of delphinidin on lipid accumulation in hepatocytes. The results showed that palmitic acid (PA)-induced cellular senescence in HepG2 cells and reduced the expression of SMARCD1, which is known to regulate senescence-associated lipid accumulation in hepatocytes. However, delphinidin-3-glucoside (D3 g) suppressed PA-induced senescence and reversed the expression of SMARCD1 to the level of untreated HepG2 cells. Consequently, D3 g inhibited PA-induced lipid accumulation through the restoration of the expression of SMARCD1 and fatty acid oxidation genes. Taken together, our results suggest that D3 g suppresses the lipid accumulation induced by hepatocyte senescence.

元の言語英語
ジャーナルCytotechnology
DOI
出版物ステータス受理済み/印刷中 - 1 1 2018

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delphinidin
Hep G2 Cells
Palmitic acid
Lipids
Palmitic Acid
Hepatocytes
Muscular Atrophy
Anthocyanins
Cell Aging
Vegetables
Fruits
Antioxidants
Fatty acids
Restoration
Fruit
Anti-Inflammatory Agents
Fatty Acids
Genes
Oxidation
delphinidin 3-O-glucopyranoside

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Clinical Biochemistry
  • Cell Biology

これを引用

Delphinidin-3-glucoside suppresses lipid accumulation in HepG2 cells. / Harada, Gakuro; Onoue, Shiori; Inoue, Chisato; Hanada, Sakae; Katakura, Yoshinori.

:: Cytotechnology, 01.01.2018.

研究成果: ジャーナルへの寄稿記事

Harada, Gakuro ; Onoue, Shiori ; Inoue, Chisato ; Hanada, Sakae ; Katakura, Yoshinori. / Delphinidin-3-glucoside suppresses lipid accumulation in HepG2 cells. :: Cytotechnology. 2018.
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AU - Hanada, Sakae

AU - Katakura, Yoshinori

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