Delphinidin prevents muscle atrophy and upregulates MIR-23a expression

Motoki Murata, Haruna Nonaka, Satomi Komatsu, Megumi Goto, Mai Morozumi, Shuhei Yamada, I. Chian Lin, Shuya Yamashita, Hirofumi Tachibana

研究成果: ジャーナルへの寄稿記事

12 引用 (Scopus)

抄録

Delphinidin, one of the major anthocyanidins, shows protective effects against a variety of pathologies, including cancer, inflammation, and muscle atrophy. The purpose of this study was to determine the preventive mechanism of delphinidin on disuse muscle atrophy. In vitro and in vivo models were used to validate the effects of delphinidin on the expression of MuRF1, miR-23a, and NFATc3. Delphinidin suppressed the upregulation of MuRF1 (1.77 ± 0.05 vs 1.03 ± 0.17, P < 0.05) expression and inhibited the downregulation of miR-23a (0.56 ± 0.05 vs 0.94 ± 0.06, P < 0.05) and NFATc3 (0.61 ± 0.02 vs 1.02 ± 0.08, P < 0.01) expression in dexamethasone-treated C2C12 cells. In gastrocnemius, muscle weight loss was prevented by oral administration of delphinidin. Moreover, delphinidin suppressed MuRF1 (3.35 ± 0.13 vs 2.26 ± 0.3, P < 0.01) expression and promoted miR-23a (0.58 ± 0.15 vs 2.25 ± 0.29, P < 0.001) and NFATc3 (0.85 ± 0.17 vs 1.54 ± 0.13, P < 0.001) expressions. Delphinidin intake may prevent disuse muscle atrophy by inducing miR-23a expression and suppressing MuRF1 expression.

元の言語英語
ページ(範囲)45-50
ページ数6
ジャーナルJournal of Agricultural and Food Chemistry
65
発行部数1
DOI
出版物ステータス出版済み - 1 1 2017

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delphinidin
muscular atrophy
Muscular Atrophy
Muscle
Up-Regulation
Atrophic Muscular Disorders
Muscle Neoplasms
anthocyanidins
Anthocyanins
Pathology
dexamethasone
oral administration
Dexamethasone
protective effect
Oral Administration
Weight Loss

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)

これを引用

Delphinidin prevents muscle atrophy and upregulates MIR-23a expression. / Murata, Motoki; Nonaka, Haruna; Komatsu, Satomi; Goto, Megumi; Morozumi, Mai; Yamada, Shuhei; Lin, I. Chian; Yamashita, Shuya; Tachibana, Hirofumi.

:: Journal of Agricultural and Food Chemistry, 巻 65, 番号 1, 01.01.2017, p. 45-50.

研究成果: ジャーナルへの寄稿記事

Murata, M, Nonaka, H, Komatsu, S, Goto, M, Morozumi, M, Yamada, S, Lin, IC, Yamashita, S & Tachibana, H 2017, 'Delphinidin prevents muscle atrophy and upregulates MIR-23a expression', Journal of Agricultural and Food Chemistry, 巻. 65, 番号 1, pp. 45-50. https://doi.org/10.1021/acs.jafc.6b03661
Murata, Motoki ; Nonaka, Haruna ; Komatsu, Satomi ; Goto, Megumi ; Morozumi, Mai ; Yamada, Shuhei ; Lin, I. Chian ; Yamashita, Shuya ; Tachibana, Hirofumi. / Delphinidin prevents muscle atrophy and upregulates MIR-23a expression. :: Journal of Agricultural and Food Chemistry. 2017 ; 巻 65, 番号 1. pp. 45-50.
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abstract = "Delphinidin, one of the major anthocyanidins, shows protective effects against a variety of pathologies, including cancer, inflammation, and muscle atrophy. The purpose of this study was to determine the preventive mechanism of delphinidin on disuse muscle atrophy. In vitro and in vivo models were used to validate the effects of delphinidin on the expression of MuRF1, miR-23a, and NFATc3. Delphinidin suppressed the upregulation of MuRF1 (1.77 ± 0.05 vs 1.03 ± 0.17, P < 0.05) expression and inhibited the downregulation of miR-23a (0.56 ± 0.05 vs 0.94 ± 0.06, P < 0.05) and NFATc3 (0.61 ± 0.02 vs 1.02 ± 0.08, P < 0.01) expression in dexamethasone-treated C2C12 cells. In gastrocnemius, muscle weight loss was prevented by oral administration of delphinidin. Moreover, delphinidin suppressed MuRF1 (3.35 ± 0.13 vs 2.26 ± 0.3, P < 0.01) expression and promoted miR-23a (0.58 ± 0.15 vs 2.25 ± 0.29, P < 0.001) and NFATc3 (0.85 ± 0.17 vs 1.54 ± 0.13, P < 0.001) expressions. Delphinidin intake may prevent disuse muscle atrophy by inducing miR-23a expression and suppressing MuRF1 expression.",
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AU - Murata, Motoki

AU - Nonaka, Haruna

AU - Komatsu, Satomi

AU - Goto, Megumi

AU - Morozumi, Mai

AU - Yamada, Shuhei

AU - Lin, I. Chian

AU - Yamashita, Shuya

AU - Tachibana, Hirofumi

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N2 - Delphinidin, one of the major anthocyanidins, shows protective effects against a variety of pathologies, including cancer, inflammation, and muscle atrophy. The purpose of this study was to determine the preventive mechanism of delphinidin on disuse muscle atrophy. In vitro and in vivo models were used to validate the effects of delphinidin on the expression of MuRF1, miR-23a, and NFATc3. Delphinidin suppressed the upregulation of MuRF1 (1.77 ± 0.05 vs 1.03 ± 0.17, P < 0.05) expression and inhibited the downregulation of miR-23a (0.56 ± 0.05 vs 0.94 ± 0.06, P < 0.05) and NFATc3 (0.61 ± 0.02 vs 1.02 ± 0.08, P < 0.01) expression in dexamethasone-treated C2C12 cells. In gastrocnemius, muscle weight loss was prevented by oral administration of delphinidin. Moreover, delphinidin suppressed MuRF1 (3.35 ± 0.13 vs 2.26 ± 0.3, P < 0.01) expression and promoted miR-23a (0.58 ± 0.15 vs 2.25 ± 0.29, P < 0.001) and NFATc3 (0.85 ± 0.17 vs 1.54 ± 0.13, P < 0.001) expressions. Delphinidin intake may prevent disuse muscle atrophy by inducing miR-23a expression and suppressing MuRF1 expression.

AB - Delphinidin, one of the major anthocyanidins, shows protective effects against a variety of pathologies, including cancer, inflammation, and muscle atrophy. The purpose of this study was to determine the preventive mechanism of delphinidin on disuse muscle atrophy. In vitro and in vivo models were used to validate the effects of delphinidin on the expression of MuRF1, miR-23a, and NFATc3. Delphinidin suppressed the upregulation of MuRF1 (1.77 ± 0.05 vs 1.03 ± 0.17, P < 0.05) expression and inhibited the downregulation of miR-23a (0.56 ± 0.05 vs 0.94 ± 0.06, P < 0.05) and NFATc3 (0.61 ± 0.02 vs 1.02 ± 0.08, P < 0.01) expression in dexamethasone-treated C2C12 cells. In gastrocnemius, muscle weight loss was prevented by oral administration of delphinidin. Moreover, delphinidin suppressed MuRF1 (3.35 ± 0.13 vs 2.26 ± 0.3, P < 0.01) expression and promoted miR-23a (0.58 ± 0.15 vs 2.25 ± 0.29, P < 0.001) and NFATc3 (0.85 ± 0.17 vs 1.54 ± 0.13, P < 0.001) expressions. Delphinidin intake may prevent disuse muscle atrophy by inducing miR-23a expression and suppressing MuRF1 expression.

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