Delta-like ligand 4-notch signaling in macrophage activation

Toshiaki Nakano, Daiju Fukuda, Jun Ichiro Koga, Masanori Aikawa

研究成果: ジャーナルへの寄稿評論記事

24 引用 (Scopus)

抜粋

The Notch signaling pathway regulates the development of various cell types and organs, and also contributes to disease mechanisms in adults. Accumulating evidence suggests its role in cardiovascular and metabolic diseases. Notch signaling components also control the phenotype of immune cells. Delta-like ligand 4 (Dll4) of the Notch pathway promotes proinflammatory activation of macrophages in vitro and in vivo. Dll4 blockade attenuates chronic atherosclerosis, vein graft disease, vascular calcification, insulin resistance, and fatty liver in mice. The Dll4-Notch axis may, thus, participate in the shared mechanisms for cardiometabolic disorders, serving as a potential therapeutic target for ameliorating these global health problems.

元の言語英語
ページ(範囲)2038-2047
ページ数10
ジャーナルArteriosclerosis, thrombosis, and vascular biology
36
発行部数10
DOI
出版物ステータス出版済み - 10 1 2016

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

これを引用