Delta-like ligand 4-notch signaling in macrophage activation

Toshiaki Nakano, Daiju Fukuda, Jun Ichiro Koga, Masanori Aikawa

研究成果: Contribution to journalReview article査読

30 被引用数 (Scopus)

抄録

The Notch signaling pathway regulates the development of various cell types and organs, and also contributes to disease mechanisms in adults. Accumulating evidence suggests its role in cardiovascular and metabolic diseases. Notch signaling components also control the phenotype of immune cells. Delta-like ligand 4 (Dll4) of the Notch pathway promotes proinflammatory activation of macrophages in vitro and in vivo. Dll4 blockade attenuates chronic atherosclerosis, vein graft disease, vascular calcification, insulin resistance, and fatty liver in mice. The Dll4-Notch axis may, thus, participate in the shared mechanisms for cardiometabolic disorders, serving as a potential therapeutic target for ameliorating these global health problems.

本文言語英語
ページ(範囲)2038-2047
ページ数10
ジャーナルArteriosclerosis, thrombosis, and vascular biology
36
10
DOI
出版ステータス出版済み - 10 1 2016
外部発表はい

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

フィンガープリント 「Delta-like ligand 4-notch signaling in macrophage activation」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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