Delta1 family members are involved in filopodial actin formation and neuronal cell migration independent of Notch signaling

Kazuya Sugiyama, Kenji Nishide, Hiromi Matsuo, Sayumi Okigawa, Makoto Okano, Tohru Ishitani, Kunihiro Matsumoto, Motoyuki Itoh

研究成果: Contribution to journalArticle査読

2 被引用数 (Scopus)

抄録

Delta family proteins are transmembrane molecules that bind Notch receptors and activate downstream signaling events in neighboring cells. In addition to serving as Notch ligands, Notch-independent roles for Delta have been suggested but are not fully understood. Here, we demonstrate a previously unrecognized role for Delta in filopodial actin formation. Delta1 and Delta4, but not Delta3, exhibit filopodial protrusive activity, and this activity is independent of Notch signaling. The filopodial activity of Delta1 does not depend on the PDZ-binding domain at the C-terminus; however, the intracellular membrane-proximal region that is anchored to the plasma membrane plays an important role in filopodial activity. We further identified a Notch-independent role of DeltaD in neuronal cell migration in zebrafish. These findings suggest a possible functional link between Notch-independent filopodial activity of Delta and the control of cell motility.

本文言語英語
ページ(範囲)118-124
ページ数7
ジャーナルBiochemical and Biophysical Research Communications
398
1
DOI
出版ステータス出版済み - 7 2010
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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