Delta(9)-tetrahydrocannabinol enhances an increase of plasma corticosterone levels induced by forced swim-stress

Kazunori Sano, Emi Koushi, Keiichi Irie, Sei Higuchi, Ryota Tsuchihashi, Junei Kinjo, Nobuaki Egashira, Ryozo Oishi, Naoki Uchida, Hiroshi Nagai, Ryoji Nishimura, Hiroyuki Tanaka, Satoshi Morimoto, Kenichi Mishima, Katsunori Iwasaki, Michihiro Fujiwara

研究成果: Contribution to journalArticle査読

12 被引用数 (Scopus)

抄録

The present study was designed to determine the effect of delta(9)-tetrahydrocannabinol (THC) on susceptibility to stress. We reported that THC significantly prolonged the immobility time during the forced swim-stress. The selective cannabinoid CB1 receptor antagonist O-2050 significantly reduced the enhancement of immobility by THC. We investigated the effect of THC on levels of stress hormone corticosterone under non-stress and forced swim-stress conditions. THC did not affect plasma corticosterone levels under non-stress conditions. However, THC, together with forced swim-stress, significantly increased plasma corticosterone levels. This effect was inhibited by O-2050. This evidence suggests that THC, under stressful conditions, enhances the susceptibility of the hypothalamus-pituitary-adrenal-axis to stress via the CB1 receptor, thereby increasing the risk of depression.

本文言語英語
ページ(範囲)2065-2067
ページ数3
ジャーナルBiological and Pharmaceutical Bulletin
32
12
DOI
出版ステータス出版済み - 12 2009

All Science Journal Classification (ASJC) codes

  • 薬理学
  • 薬科学

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