Depth and time-dependent heterogeneity of microglia in mouse hippocampal slice cultures

Yuka Kasahara, Ryuta Koyama, Yuji Ikegaya

研究成果: Contribution to journalArticle査読

10 被引用数 (Scopus)

抄録

Microglia are the brain-resident immune cells with the phagocytic capacity to engulf dead and living neurons in health and disease. However, the mechanisms underlying the neuron-microglia interaction remain elusive partly because proper in vitro systems are lacking. Specifically, the highly activated status of microglia with amoeboid morphology in primary culture is different from the ‘resting’ microglia with multiple processes in vivo. Here, we performed a detailed investigation of microglial properties in mouse hippocampal slice cultures, focusing on the changes in morphology in the activated state, finding a depth and time-dependent localization of in vivo-like microglia in slice cultures.

本文言語英語
ページ(範囲)64-69
ページ数6
ジャーナルNeuroscience Research
111
DOI
出版ステータス出版済み - 10 1 2016
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)

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