Design and synthesis of new mitochondrial cytotoxin N-thiadiazolylanilines that inhibit tumor cell growth

Hitoshi Hori, Naoto Noguchi, Hideakira Yokoyama, Hirohiko Ise, Cheng Zhe Jin, Soko Kasai, Takatsugu Goto, Zenei Taira

研究成果: ジャーナルへの寄稿学術誌査読

3 被引用数 (Scopus)

抄録

New N-thiadiazolylanilines were designed and synthesized to develop mitochondrial cytotoxins superior to SF 6847. The mitochondrial cytotoxin N-thiadiazolylanilines, TX-108 and TX-109, inhibited EMT6/KU mammary sarcoma cell growth at a low micromolar concentration. Their inhibitory activities were parallel to their mitochondrial cytotoxicity, such as uncoupling oxidative phosphorylation and inhibiting ATP synthesis. This report also supports the notion that the inhibition of tumor cell growth of inhibitor of protein tyrosine kinase AG17, which is identical to SF 6847, may be due to its mitochondrial cytotoxicity.

本文言語英語
ページ(範囲)247-253
ページ数7
ジャーナルBioorganic and Medicinal Chemistry
4
2
DOI
出版ステータス出版済み - 1月 1 1996
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 生化学
  • 分子医療
  • 分子生物学
  • 薬科学
  • 創薬
  • 臨床生化学
  • 有機化学

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