Design of a 15 N Molecular Unit to Achieve Long Retention of Hyperpolarized Spin State

Hiroshi Nonaka, Masashi Hirano, Yuki Imakura, Yoichi Takakusagi, Kazuhiro Ichikawa, Shinsuke Sando

    研究成果: Contribution to journalArticle査読

    29 被引用数 (Scopus)

    抄録

    Nuclear hyperpolarization is a phenomenon that can be used to improve the sensitivity of magnetic resonance molecular sensors. However, such sensors typically suffer from short hyperpolarization lifetime. Herein we report that [ 15 N, D 14 ]trimethylphenylammonium (TMPA) has a remarkably long spin-lattice relaxation time (1128 s, 14.1 T, 30 °C, D 2 O) on its 15 N nuclei and achieves a long retention of the hyperpolarized state. [ 15 N, D 14 ]TMPA-based hyperpolarized sensor for carboxylesterase allowed the highly sensitive analysis of enzymatic reaction by 15 N NMR for over 40 min in phophate-buffered saline (H 2 O, pH 7.4, 37 °C).

    本文言語英語
    論文番号40104
    ジャーナルScientific reports
    7
    DOI
    出版ステータス出版済み - 1 9 2017

    All Science Journal Classification (ASJC) codes

    • 一般

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