Design of an injectable in situ gelation biomaterials for vitreous substitute

Masahiko Annaka, Kell Mortensen, Martin E. Vigild, Toyoaki Matsuura, Souichiro Tsuji, Tetsuo Ueda, Hiroki Tsujinaka

研究成果: ジャーナルへの寄稿記事

18 引用 (Scopus)

抄録

To adapt the physical properties of living materials to their biological function, nature developed various types of polymers with outstanding physical behavior. One example is the vitreous body, which is important intraocular elements not only because of its optical and mechanical performances, but also due to its important role in the pathogenesis and treatment of conditions affecting adjacent tissues and eventually the whole eye. Here, we report a novel biocompatible material for injectable vitreous substitute, composed of thermosensitive amphiphilic polymer, which is capable of forming a transparent gel in the vitreous cavity. It is nontoxic, provides adequate support for the retina, and allows light to reach the sensory elements at the back of the eye. The amphiphilic polymer exhibits mechanical stability by assembling to form highly interconnected hydrophobic domains, which leads to the constitution of a network structure.

元の言語英語
ページ(範囲)4011-4021
ページ数11
ジャーナルBiomacromolecules
12
発行部数11
DOI
出版物ステータス出版済み - 11 14 2011

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Biocompatible Materials
Gelation
Biomaterials
Polymers
Mechanical stability
Gels
Physical properties
Tissue

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

これを引用

Annaka, M., Mortensen, K., Vigild, M. E., Matsuura, T., Tsuji, S., Ueda, T., & Tsujinaka, H. (2011). Design of an injectable in situ gelation biomaterials for vitreous substitute. Biomacromolecules, 12(11), 4011-4021. https://doi.org/10.1021/bm201012f

Design of an injectable in situ gelation biomaterials for vitreous substitute. / Annaka, Masahiko; Mortensen, Kell; Vigild, Martin E.; Matsuura, Toyoaki; Tsuji, Souichiro; Ueda, Tetsuo; Tsujinaka, Hiroki.

:: Biomacromolecules, 巻 12, 番号 11, 14.11.2011, p. 4011-4021.

研究成果: ジャーナルへの寄稿記事

Annaka, M, Mortensen, K, Vigild, ME, Matsuura, T, Tsuji, S, Ueda, T & Tsujinaka, H 2011, 'Design of an injectable in situ gelation biomaterials for vitreous substitute', Biomacromolecules, 巻. 12, 番号 11, pp. 4011-4021. https://doi.org/10.1021/bm201012f
Annaka M, Mortensen K, Vigild ME, Matsuura T, Tsuji S, Ueda T その他. Design of an injectable in situ gelation biomaterials for vitreous substitute. Biomacromolecules. 2011 11 14;12(11):4011-4021. https://doi.org/10.1021/bm201012f
Annaka, Masahiko ; Mortensen, Kell ; Vigild, Martin E. ; Matsuura, Toyoaki ; Tsuji, Souichiro ; Ueda, Tetsuo ; Tsujinaka, Hiroki. / Design of an injectable in situ gelation biomaterials for vitreous substitute. :: Biomacromolecules. 2011 ; 巻 12, 番号 11. pp. 4011-4021.
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