Design of artificial metalloenzymes using non-covalent insertion of a metal complex into a protein scaffold

Takafumi Ueno, Tomomi Koshiyama, Satoshi Abe, Norihiko Yokoi, Masataka Ohashi, Hiroshi Nakajima, Yoshihito Watanabe

研究成果: Contribution to journalArticle査読

63 被引用数 (Scopus)

抄録

Construction of artificial metalloenzymes is one of the most attractive targets in the field of inorganic and catalytic chemistry, since they show remarkable chemoselectivity and reactivity in aqueous media. For the purpose, covalent modification of protein and cofactors have usually been utilized to attach a metal complex(es) to a protein scaffold. This article focuses on non-covalent insertion of metal complexes into protein environments. The discussion includes the screening of stable metal complex/protein composites, crystal structures, molecular design for regulating enantioselectivity of the target catalytic reactions. Our recent results show that the non-covalent conjugation will provide us a new way in semi-synthesis of artificial metalloenzymes.

本文言語英語
ページ(範囲)142-147
ページ数6
ジャーナルJournal of Organometallic Chemistry
692
1-3
DOI
出版ステータス出版済み - 1 1 2007

All Science Journal Classification (ASJC) codes

  • 生化学
  • 物理化学および理論化学
  • 有機化学
  • 無機化学
  • 材料化学

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