Design of biocompatible and biodegradable polymers based on intermediate water concept

Polymeric biomaterials have significant impact in the aged society. Biocompatible and biodegradable polymers have emerged during the past decades to promise extraordinary breakthroughs in a wide range of diagnostic and therapeutic medical devices. Understanding and controlling the interfacial interactions of the polymeric biomaterials with biological elements, such as water, ions, proteins, bacteria, fungai and cells, are essential toward their successful implementation in biomedical applications. Here we highlight the recent developments of biocompatible and biodegradable fusion polymeric biomaterials for medical devices and provide an overview of the recent progress of the design of the multi-functional biomedical polymers by controlling bio-interfacial water structure through precision polymer synthesis and supramolecular chemistry.