Design of highly efficient and selective transfer reaction of nitrosyl group to dC and dMC resulting in specific deamination

Md Monsur Ali, Fumi Nagatsugi, Shizuka Nakayama, Md Rowshon Alam, Takeshi Kawasaki, Shigeki Sasaki

研究成果: Contribution to journalArticle査読

1 被引用数 (Scopus)

抄録

Nitric oxide (NO) is an important endogenous regulatory molecule, and S-nitrosothiols are believed to play a significant role in NO storage, transport, and delivery. Based on the ability to generate NO in vivo, S-nitrosothiols can be used as therapeutic drugs. In this study, we have developed an innovative method for sequence- and base-specific delivery of NO to a specific site of DNA followed by specific deamination.

本文言語英語
ページ(範囲)721-724
ページ数4
ジャーナルNucleosides, Nucleotides and Nucleic Acids
24
5-7
DOI
出版ステータス出版済み - 2005
外部発表はい

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Genetics

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