Design of new inhibitors for cdc2 kinase based on a multiple pseudosubstrate structure

Shigeki Sasaki, Tomohiro Hashimoto, Norihiro Obana, Hideyo Yasuda, Yoshimasa Uehara, Minoru Maeda

研究成果: Contribution to journalArticle査読

18 被引用数 (Scopus)

抄録

New inhibitors have been designed for cdc2 kinase based on a multiple pseudosubstrate structure. The new inhibitors have three different structural components: 3,4-bis(indol-3-yl)maleimide, Ac-Cys-(Ser)-Pro-Lys-Lys-NHMe, and ethyloxy group between the two components. Inhibitory activities toward cdc2 and other protein kinases were investigated, and the compound (21) with Ac- Cys-Pro-Lys-Lys-NHMe connected with the triethylene glycol spacer exhibited the most potent inhibition with relatively high selectivity.

本文言語英語
ページ(範囲)1019-1022
ページ数4
ジャーナルBioorganic and Medicinal Chemistry Letters
8
9
DOI
出版ステータス出版済み - 5 1 1998

All Science Journal Classification (ASJC) codes

  • 生化学
  • 分子医療
  • 分子生物学
  • 薬科学
  • 創薬
  • 臨床生化学
  • 有機化学

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