Design of novel biointerfaces (II). Fabrication of self-organized porous polymer film with highly uniform pores

Masaru Tanaka, Masafumi Takebayashi, Masashi Miyama, Jin Nishida, Masatsugu Shimomura

研究成果: Contribution to journalArticle査読

83 被引用数 (Scopus)

抄録

Application of porous polymer materials to novel bio-interfaces for tissue engineering scaffold and artificial organs including blood filters, dialyzer, and oxygenator membranes have been in progress. The present study describes the fabrication and characterization of self-organized highly regular porous polymer films with uniform pore sizes are prepared by simple casting technique. Various fabrication parameters affecting the pore size such as polymer concentration, boiling point of solvent, cast volume and substrate are studied. The pore size can be controlled in the range from 1 to 50 μm by changing the evaporation rate of the polymer solutions. The porous film with uniform pore size is used for tissue engineering scaffold and cell separation membrane. To simulate the leukocyte eliminating from human blood, the porous film was attached to a module. The films with 5-9 μm pores provided the complete selectivity of separation for the leukocyte from the whole blood. The leukocyte elimination ratio depends on pore structures (size and depth) as well as recovery of platelet and erythrocyte.

本文言語英語
ページ(範囲)439-446
ページ数8
ジャーナルBio-Medical Materials and Engineering
14
4
出版ステータス出版済み - 12 1 2004
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生体材料
  • 生体医工学

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