Design of novel zinc finger proteins: Towards artificial control of specific gene expression

M. Imanishi, Y. Hori, M. Nagaoka, Y. Sugiura

研究成果: ジャーナルへの寄稿総説査読

20 被引用数 (Scopus)

抄録

In this review, we summarize design strategies for generating proteins with desired sequences such as long contiguous base pairs and diverse sequence specificities based on the nature of Cys2-His2 zinc finger proteins. Recent progress towards artificial DNA binding proteins has been achieved by structure-based design processes and by selection strategies. Indeed, a multi-zinc finger protein with an 18 (or 27)-base pair address, and new zinc finger proteins for diverse DNA target sites (TATA-box and p53 binding site) have been created successfully. Such novel zinc finger proteins will probably be useful tools in molecular biology and potentially in human medicine.

本文言語英語
ページ(範囲)91-97
ページ数7
ジャーナルEuropean Journal of Pharmaceutical Sciences
13
1
DOI
出版ステータス出版済み - 2001
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 薬科学

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