Design of Polymeric Biomaterials: The "Intermediate Water Concept"

Masaru Tanaka, Shingo Kobayashi, Daiki Murakami, Fumihiro Aratsu, Aki Kashiwazaki, Takashi Hoshiba, Kazuki Fukushima

研究成果: Contribution to journalReview article査読

12 被引用数 (Scopus)


When biomaterials come into contact with biological fluids, water molecules immediately adsorb onto the surface of the materials. To understand the origin of the crucial roles of water molecules in biological interfaces, it is necessary to relate particular states of hydration water to various physicochemical properties of hydrated polymers. Here, advances in the inter-mediate water concept are reviewed. This account provides an overview of the progress made in the design of multi-functional biomedical polymers by controlling the bio-interfacial water states. Using principles of intermediate water, which is common in hydrated biopolymers and only biocompatible synthetic polymers, we found the synthetic methodology to create novel biocompatible polymers moves toward a more high-throughput way.

ジャーナルBulletin of the Chemical Society of Japan
出版ステータス出版済み - 1 1 2019

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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