Design of synthetic polymer nanoparticles that capture and neutralize a toxic peptide

Yu Hoshino, Takeo Urakami, Takashi Kodama, Hiroyuki Koide, Naoto Oku, Yoshio Okahata, Kenneth J. Shea

研究成果: Contribution to journalArticle査読

75 被引用数 (Scopus)

抄録

Designed polymer nanoparticles (NPs) capable of binding and neutralizing a biomacromolecular toxin are prepared. A library of copolymer NPs is synthesized from combinations of functional monomers. The binding capacity and affinity of the NPs are individually analyzed. NPs with optimized composition are capable of neutralizing the toxin even in a complex biological milieu. It is anticipated that this strategy will be a starting point for the design of synthetic alternatives to antibodies.

本文言語英語
ページ(範囲)1562-1568
ページ数7
ジャーナルSmall
5
13
DOI
出版ステータス出版済み - 7 3 2009

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)

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