Design, synthesis, and application of a C2 symmetric chiral ligand for enantioselective conjugate addition of organolithium to α,β-unsaturated aldimine

Mitsuru Shindo, Kenji Koga, Kiyoshi Tomioka

研究成果: Contribution to journalArticle査読

108 被引用数 (Scopus)

抄録

A C2 symmetric chiral diether ligand, (1R,2R)-1,2-dimethoxy-1,2- diphenylethane, was designed and synthesized on the basis of the concept of an asymmetric oxygen atom. Mediated by the chiral diether, high enantioselectivities were achieved in conjugate addition of organolithiums to naphthaldehyde imine and cyclic and acyclic α,β-unsaturated aldimines. The absolute configuration of the product is predictable by the model.

本文言語英語
ページ(範囲)9351-9357
ページ数7
ジャーナルJournal of Organic Chemistry
63
25
DOI
出版ステータス出版済み - 12 11 1998
外部発表はい

All Science Journal Classification (ASJC) codes

  • 有機化学

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