Design, synthesis and characterization of a novel fluorescent probe for nitric oxide (nitrogen monoxide)

Yoshiki Katayama, Shinji Takahashi, Mizuo Maeda

研究成果: ジャーナルへの寄稿記事

30 引用 (Scopus)

抄録

The iron(II) complex of quinoline pendant cyclam was designed as a mimic of the activation site of guanylate cyclase and synthesized as a fluorescent probe for nitric oxide (NO). Fe(II) ion shifted the excitation and emission maxima of the pendant fluorophore to longer wavelengths, and the fluorescence intensity was greatly increased. NO from NO-releasing agents quenched the fluorescence effectively. Nitrite, which is a metabolite of NO, did not affect the fluorescence of the complex. Cyanate also did not affect the spectral change of the complex with NO. NO, as low as μM, can be determined spectrofluorimetrically using 200μM reagent. This is the first example of a fluorescent probe for NO which recognizes the molecule directly. Copyright (C) 1998 Elsevier Science B.V.

元の言語英語
ページ(範囲)159-167
ページ数9
ジャーナルAnalytica Chimica Acta
365
発行部数1-3
DOI
出版物ステータス出版済み - 6 5 1998

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nitric oxide
Fluorescent Dyes
Nitric Oxide
probe
fluorescence
Fluorescence
Cyanates
Fluorophores
Guanylate Cyclase
Metabolites
Nitrites
nitrogen monoxide
nitrite
metabolite
Iron
Chemical activation
Ions
wavelength
iron
Wavelength

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Environmental Chemistry
  • Biochemistry
  • Spectroscopy

これを引用

Design, synthesis and characterization of a novel fluorescent probe for nitric oxide (nitrogen monoxide). / Katayama, Yoshiki; Takahashi, Shinji; Maeda, Mizuo.

:: Analytica Chimica Acta, 巻 365, 番号 1-3, 05.06.1998, p. 159-167.

研究成果: ジャーナルへの寄稿記事

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