Design, synthesis and cytotoxic evaluation of o-carboxamido stilbene analogues

Mohamad Nurul Azmi, Mohd Fadzli Md Din, Chin Hui Kee, Munirah Suhaimi, Ang Kheng Ping, Kartini Ahmad, Mohd Azlan Nafiah, Noel F. Thomas, Khalit Mohamad, Leong Kok Hoong, Khalijah Awang

    研究成果: Contribution to journalArticle査読

    13 被引用数 (Scopus)

    抄録

    Resveratrol, a natural stilbene found in grapes and wines exhibits a wide range of pharmacological properties. Resveratrol is also known as a good chemopreventive agent for inhibiting carcinogenesis processes that target kinases, cyclooxygenases, ribonucleotide reductase and DNA polymerases. A total of 19 analogues with an amide moiety were synthesized and the cytotoxic effects of the analogues on a series of human cancer cell lines are reported. Three compounds 6d, 6i and 6n showed potent cytotoxicity against prostate cancer DU-145 (IC50 = 16.68 μM), colon cancer HT-29 (IC50 = 7.51 μ M) and breast cancer MCF-7 (IC50 = 21.24 μM), respectively, which are comparable with vinblastine. The resveratrol analogues were synthesized using the Heck method.

    本文言語英語
    ページ(範囲)23369-23389
    ページ数21
    ジャーナルInternational journal of molecular sciences
    14
    12
    DOI
    出版ステータス出版済み - 11 27 2013

    All Science Journal Classification (ASJC) codes

    • 触媒
    • 分子生物学
    • 分光学
    • コンピュータ サイエンスの応用
    • 物理化学および理論化学
    • 有機化学
    • 無機化学

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