Design, synthesis and evaluation of novel azasugar-based MMP/ADAM inhibitors

Hideki Moriyama, Takahiro Tsukida, Yoshimasa Inoue, Hirosato Kondo, Kohichiro Yoshino, Shin Ichiro Nishimura

研究成果: Contribution to journalArticle査読

16 被引用数 (Scopus)

抄録

In order to verify whether azasugar would be a useful scaffold for inhibitory activity against metalloproteinases, we synthesized some azasugar-based compounds. As a result, it is clarified that azasugar moiety could function as successful inhibitor of matrix metalloproteinase-1, -3 and -9 and TACE.

本文言語英語
ページ(範囲)2741-2744
ページ数4
ジャーナルBioorganic and Medicinal Chemistry Letters
13
16
DOI
出版ステータス出版済み - 8 18 2003
外部発表はい

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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