Detection and inhibition of redox reaction and lipid derived radicals

研究成果: Contribution to journalArticle査読

抄録

In development of many oxidative disease, change of redox reaction and generation of free radicals have been reported to be involved. Here, for detection of redox status and free radical reaction (especially, lipid-derived radicals), we focus on nitroxide compounds having stable unpaired electrons in the molecule. Since this molecule can react with redox compounds or bind with carbon-centered radicals, we can use a detection probe for these molecules in experimental animal models. In this paper, we show that lipid-derived radicals are generated during induction of chemical carcinogenesis and light-induced retinal damages in animal models using this probes, and this information will provide the timing of inhibitor injection to the animals. In other words, we will explain the study of theranostics through detection and inhibition of lipid-derived radicals.

本文言語英語
ページ(範囲)197-203
ページ数7
ジャーナルDrug Delivery System
33
3
DOI
出版ステータス出版済み - 1 1 2018

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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