Detection and visualization of food-derived polyphenols by matrix-assisted laser desorption/ionization mass spectrometry imaging

Huu Nghi Nguyen, Tae Hun Ham, Toshiro Matsui, Mitsuru Tanaka

研究成果: ジャーナルへの寄稿学術誌査読

2 被引用数 (Scopus)

抄録

Food-derived polyphenols have health benefits owing to their ability to prevent some diseases. Knowledge of their bioavailabilities and metabolism is important for understanding the mechanisms underlying their benefits. Thus, mass spectrometry (MS)-based analytical techniques, such as liquid chromatography-MS (LC-MS), that are capable of highly sensitive and simultaneous detection of absorbed polyphenols and their metabolites are essential tools in this field. Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) imaging is currently used in biological sciences for visualizing the spatial information of various compounds, such as peptides, proteins, lipids, drugs, and food compounds, in various biological tissues. However, the application of MALDI-MS imaging to polyphenols is challenging owing to the lack of appropriate matrix reagents for visualizing (or detecting) polyphenols absorbed in target biological tissues. This review highlights the development of the MALDI-MS imaging technique for the detection and visualization of food-derived polyphenols. First, the development of new matrices and matrix additives for the detection and visualization of polyphenols is discussed, followed by their introduction to inhibitor-aided MALDI-MS imaging for the elucidation of intestinal absorption routes and the metabolic behaviors of polyphenols. The MALDI-MS imaging technique shows great potential as a novel analytical tool for elucidating the bioavailabilities of food-derived polyphenols.

本文言語英語
ページ(範囲)2333-2346
ページ数14
ジャーナルSensors and Materials
31
7
DOI
出版ステータス出版済み - 2019

!!!All Science Journal Classification (ASJC) codes

  • 器械工学
  • 材料科学(全般)

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