Detection of amiodarone-induced pulmonary toxicity in supine and prone positions - High-resolution computed tomography study

Noriko Oyama, Naotsugu Oyama, Hisashi Yokoshiki, Tamotsu Kamishima, Toshikazu Nambu, Hiroyuki Tsutsui, Kazuo Miyasaka

研究成果: Contribution to journalArticle査読

26 被引用数 (Scopus)

抄録

Background: The aim of the present study was to describe the effectiveness and feasibility of high-resolution computed tomography (HRCT) in patients in supine and prone positions to detect amiodarone-induced pulmonary toxicity (APT). With regard to the possible differential diagnosis, our second goal was to emphasize the clinical value of HRCT with the patients in supine and prone positions compared with other paraclinical tests. Methods and Results: Thoracic HRCT taken in both positions for 23 patients who were administrated amiodarone were prospectively evaluated in the current study. High-resolution computed tomography scans obtained with the patient in a prone position were helpful in differentiating dependent opacity from lung disease in 11 out of 23 patients. In another 4 patients, HRCT scans obtained with the patient in a prone position were useful in confirming the presence of subtle ground-glass opacities, considered as APT. Combination of HRCT in supine and prone positions provided a more reproducible method for evaluating the global extent of APT than other paraclinical tests. Conclusions: High-resolution computed tomography used in prone positions as well as a supine position could be an effective technique for reducing false-positive results in detection of APT and preventing the clinically serious pulmonary adverse effects by amiodanone.

本文言語英語
ページ(範囲)466-470
ページ数5
ジャーナルCirculation Journal
69
4
DOI
出版ステータス出版済み - 4 2005
外部発表はい

All Science Journal Classification (ASJC) codes

  • 循環器および心血管医学

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