Determination of bromide in whole blood and urine from humans using gas chromatography-mass spectrometry

Shigetoshi Kage, Keiko Kudo, Hideaki Ikeda, Akira Tsujita, Noriaki Ikeda

研究成果: Contribution to journalArticle査読

7 被引用数 (Scopus)

抄録

We devised a sensitive and simple method for determination of bromide in whole blood and urine from humans using gas chromatography-mass spectrometry. Bromide was alkylated with pentafluorobenzyl p-toluenesulphonate in the mixture of acetone and phosphate buffer (pH 6.8). The derivative obtained was analyzed using gas chromatography-mass spectrometry with the positive-ion EI mode. The lower limit of detection for the compound was 1 mg/l. The calibration curve for bromide was linear over the concentration range from 2 to 100 mg/l. With use of this method, levels of bromide in whole blood and urine were determined in cases of poisoning by inhaled brominated hydrocarbons.

本文言語英語
ページ(範囲)335-339
ページ数5
ジャーナルJournal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
817
2
DOI
出版ステータス出版済み - 3 25 2005

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry
  • Cell Biology

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