Determination of Fragrance Allergens by Ultraviolet Femtosecond Laser Ionization Mass Spectrometry

Shimpei Shibuta, Tomoko Imasaka, Totaro Imasaka

研究成果: ジャーナルへの寄稿記事

9 引用 (Scopus)

抄録

The allergenic compounds listed in the Cosmetics Directive by the Scientific Committee for Consumer Safety were analyzed by gas chromatography combined with multiphoton ionization mass spectrometry using a femtosecond laser emitting at 200 and 267 nm as the ionization source. The limits of detection were less than 100 pg/μL for all of the compounds, permitting them to be measured in actual samples that were simply prepared by a 100-fold dilution of the original sample. The ionization process was investigated for the 26 allergens, some of which had no absorption band, even in the far-UV region. As a result, nonresonant two-photon ionization was found to be the most sensitive and universal method for the trace analysis of these compounds, because of the short pulse width, i.e., a high peak power, of the femtosecond laser used. It should be noted that the excess energy can be reduced by using a laser emitting at longer wavelengths (267 nm) and that fragmentation can be suppressed, especially for a molecule that contains a long side chain. Three commercially available perfumes were measured, and more than 10 allergenic compounds were determined.

元の言語英語
ページ(範囲)10693-10700
ページ数8
ジャーナルAnalytical Chemistry
88
発行部数21
DOI
出版物ステータス出版済み - 11 1 2016

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Fragrances
Ultrashort pulses
Allergens
Ionization
Mass spectrometry
Trace analysis
Cosmetics
Ion sources
Gas chromatography
Dilution
Absorption spectra
Photons
Wavelength
Molecules
Lasers

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry

これを引用

Determination of Fragrance Allergens by Ultraviolet Femtosecond Laser Ionization Mass Spectrometry. / Shibuta, Shimpei; Imasaka, Tomoko; Imasaka, Totaro.

:: Analytical Chemistry, 巻 88, 番号 21, 01.11.2016, p. 10693-10700.

研究成果: ジャーナルへの寄稿記事

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